2. Cell Cycle/DNA Damage Anti-infection
  3. DNA/RNA Synthesis CMV
  4. PMEG

PMEG 是一种作用于细胞核的 DNA 聚合酶 α、δ 和 ε (DNA polymerases α/δ/ε) 的抑制剂，可导致 DNA 链终止，抑制 DNA 合成，并在增殖细胞中诱导细胞毒性。PMEG 是一种非环状核苷膦酸酯，在细胞内可转化为具有活性的磷酸化代谢物 PMEG 二磷酸。PMEG 在啮齿类动物模型中对白血病和黑色素瘤具有活性。PMEG 细胞渗透性较差，其前药为 Rabacfosadine (GS-9219) (HY-13640)。PMEG 对多种 DNA 病毒感染表现出抗病毒活性，包括小鼠巨细胞病毒 (MCMV) 和人类巨细胞病毒 (HCMV)。PMEG 可用于非霍奇金淋巴瘤研究。

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PMEG

PMEG Chemical Structure

CAS No. : 114088-58-3

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PMEG 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PMEG is a nuclear DNA polymerases α, δ, and ε inhibitor that causes DNA chain termination, inhibits DNA synthesis, induces cytotoxicity in dividing cells. PMEG is an acyclic nucleotide phosphonate that forms an active phosphorylated metabolite, PMEG diphosphate, within cells. PMEG has activity against leukemia and melanoma in rodent models. PMEG has poor cell permeability; its prodrug is Rabacfosadine (GS-9219) (HY-13640). PMEG shows antiviral activity against against various DNA virus infections including murine cytomegalovirus (MCMV) and human cytomegalovirus (HCMV). PMEG can be used for the research of non-hodgkin's lymphoma[1][2].

体内研究
(In Vivo)

Rabacfosadine (GS-9219) (HY-13640) (0.20-0.82 mg/kg；静脉输注 30 分钟) 可在淋巴样细胞内大量蓄积 PMEG，并能使患有自发性非霍奇金淋巴瘤的家养宠物犬达到缓解 (缓解率为 79%)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

289.19

Formula

C8H12N5O5P
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PMEG 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PMEG114088-58-39-(2-Phosphonylmethoxy)ethylguanineDNA/RNA SynthesisCMVCytomegaloviruslymphoid cellsDNA synthesisdividing cellsleukemiarodent modelsclient-owned pet dogscytotoxicityanticancer agentεhigh-proliferation lymphoid malignanciesnon-hodgkin's lymphomaspontaneous non-Hodgkin's lymphomanuclear DNA polymerases αδDNA chain terminationmelanomaInhibitorinhibitorinhibit

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