2. Cell Cycle/DNA Damage Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease NF-κB Immunology/Inflammation
  3. PPAR NF-κB NOD-like Receptor (NLR) NEKs
  4. PPARγ agonist-21

PPARγ agonist-21 (Compound 9a) 是一种 PPARγ 激动剂，其 EC50 值为 3.12 μM。PPARγ agonist-21 通过激活 PPAR-γ 来抑制 NF-κB 并减弱 NLRP3 炎症小体 (NLRP3 inflammasome) 的组装。PPARγ agonist-21 可阻断 NLRP3-ASC 和 NLRP3-NEK7 之间的相互作用。PPARγ agonist-21 可减轻痛风性关节炎的严重程度。

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PPARγ agonist-21

PPARγ agonist-21 Chemical Structure

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PPARγ agonist-21 相关抗体

Top Publications Citing Use of Products

查看 PPAR 亚型特异性产品:

查看所有亚型
PPARα PPARβ/δ PPARγ PPAR PPARδ

查看 NF-κB 亚型特异性产品:

查看所有亚型
NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

查看 NOD-like Receptor (NLR) 亚型特异性产品:

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NLRP3 NLRP1 NOD1 NOD2

查看 NEKs 亚型特异性产品:

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NEK1 NEK2 NEK6 NEK7

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PPARγ agonist-21 (Compound 9a) is a PPARγ agonist with an EC50 of 3.12 μM. PPARγ agonist-21 activates PPAR-γ to inhibit NF-κB and attenuate NLRP3 inflammasome assembly. PPARγ agonist-21 blocks NLRP3-ASC and NLRP3-NEK7 interaction. PPARγ agonist-21 attenuates the severity of gouty arthritis[1].

IC50 & Target[1]

PPAR-γ

3.12 μM (EC50)

NF-κB

 

NLRP3 inflammasome

 

NEK7

 

分子量

433.25

Formula

C19H17BrN2O5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PPARγ agonist-21 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PPARγ agonist-21PPARγ agonist21PPARγ agonist 21PPARNF-κBNOD-like Receptor (NLR)NEKsPeroxisome proliferator-activated receptorsNuclear factor-κBNuclear factor-kappaBNIMA–related KinasesNIMA (never in mitosis gene a)-related Expressed Kinasesgouty arthritisInhibitorinhibitorinhibit

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