2. PROTAC Epigenetics Apoptosis
  3. PROTACs Epigenetic Reader Domain Apoptosis c-Myc
  4. PROTAC BRD4 Degrader-41

PROTAC BRD4 Degrader-41 (Compound A5) 是一种 BRD4 PROTAC 降解剂，其 DC50 为 0.97 nM。PROTAC BRD4 Degrader-41 对 AML、淋巴瘤、乳腺癌、卵巢癌、非小细胞肺癌等多种癌细胞均有强效的抗增殖活性。PROTAC BRD4 Degrader-41 可诱导 MV4-11 细胞发生 G0/G1 期阻滞和细胞凋亡 (apoptosis)。PROTAC BRD4 Degrader-41 下调 c-Myc 的转录水平。
(粉色: BRD4 配体 (HY-78695)；蓝色: Ligands for E3 Ligase 配体 (HY-179735)；黑色: 连接子)。

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PROTAC BRD4 Degrader-41

PROTAC BRD4 Degrader-41 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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PROTAC BRD4 Degrader-41 相关抗体

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查看 PROTACs 亚型特异性产品:

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PROTAC BRD4 Degrader-41 (Compound A5) is a BRD4 PROTAC degrader with a DC50 of 0.97 nM. PROTAC BRD4 Degrader-41 exhibits potent anti-proliferative activity against various types of cancer cells such as AML, lymphoma, breast cancer, ovarian cancer, and non-small cell lung cancer. PROTAC BRD4 Degrader-41 can induce G0/G1 phase arrest and apoptosis in MV4-11 cells. PROTAC BRD4 Degrader-41 downregulates the transcriptional level of c-Myc[1]. (Pink: BRD4 ligand (HY-78695); Blue: Ligands for E3 Ligase ligand (HY-179735); Black: linker).

IC50 & Target[1]

BRD4

0.97 nM (DC50)

Cereblon

 

分子量

827.43

Formula

C43H51ClN8O5S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PROTAC BRD4 Degrader-41 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC BRD4 Degrader-41PROTACsEpigenetic Reader DomainApoptosisc-MycMycacute myeloid leukemiaFLT3-ITD mutationCD15CD4CD10IMDM mediumIL-3GM-CSFG-CSFdrug screeningsignal pathway analysisInhibitorinhibitorinhibit

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产品名称：
PROTAC BRD4 Degrader-41
目录号：
HY-179734
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