2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease Apoptosis Autophagy
  3. Reactive Oxygen Species (ROS) Apoptosis ER-phagy
  4. Pt(II)-NHC complex 2C

Pt(II)-NHC complex 2C  (Synonyms: Platinum(II)-N-heterocyclic carbene complex 2C)

目录号: HY-175048
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Pt(II)-NHC Complex 2C (Platinum(II)-N-Heterocyclic carbene complex 2C) (Compound 2C) 是一种基于 N-杂环卡宾 (NHC) 的铂 (II) 配合物。Pt(II)-NHC Complex 2C 是一种免疫原性细胞死亡 (ICD) 诱导剂，可诱导肝癌细胞内质网应激 (ERS) 并产生 ROS，最终导致损伤相关分子模式 (DAMP) 的释放。Pt(II)-NHC Complex 2C 将细胞周期阻滞在 S 期，并显著诱导细胞凋亡 (apoptosis)。Pt(II)-NHC Complex 2C 在小鼠模型中显示出抗肝癌潜力，并在肝损伤模型中激活了免疫细胞。

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Pt(II)-NHC complex 2C

Pt(II)-NHC complex 2C Chemical Structure

CAS No. : 3035433-94-1

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生物活性

Pt(II)-NHC Complex 2C (Platinum(II)-N-Heterocyclic Carbene complex 2C) (Compound 2C) is a platinum(II) complex based on N-heterocyclic carbene (NHC). Pt(II)-NHC Complex 2C is an immunogenic cell death (ICD) inducer that can induce endoplasmic reticulum stress (ERS) in liver cancer cells and produce reactive oxygen species (ROS), ultimately leading to the release of damage-associated molecular patterns (DAMP). Pt(II)-NHC Complex 2C blocks the cell cycle at the S phase and significantly induces cell apoptosis. Pt(II)-NHC Complex 2C shows anti-liver cancer potential in mouse models and activates immune cells in liver injury models.

分子量

840.35

Formula

C24H23F2I2N3Pt
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
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Keywords:

Pt(II)-NHC complex 2C3035433-94-1Platinum(II)-N-heterocyclic carbene complex 2CReactive Oxygen Species (ROS)ApoptosisER-phagyEndoplasmic reticulum autophagyPt(II)-N-heterocyclic carbene (Pt-NHC)immunogenic cell death (ICD)hepatocellular carcinoma (HCC)reactive oxygen species (ROS)Inhibitorinhibitorinhibit

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