2. GPCR/G Protein
  3. RXFP Receptor
  4. R9-13

R9-13 是一种脂肪酸耦连的松弛素 (relaxin)，是一种 LGR7 (RXFP1) 激活剂。R9-13 可诱导经雌激素预处理的小鼠中驱动耻骨韧带持续伸长。R9-13 在啮齿类动物中表现出长效药代动力学特征，给药后体内活性可持续长达一周。R9-13 可用于急性心力衰竭的相关研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Custom Peptide Synthesis

R9-13

R9-13 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

R9-13 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

R9-13 is a fatty acid-conjugated relaxin and an agonist of LGR7 (RXFP1). R9-13 induces sustained pubic symphysis elongation in estrogen-pretreated mice. R9-13 exhibits long-acting pharmacokinetic profiles in rodents, with in vivo activity lasting up to one week after administration. R9-13 can be used in studies related to acute heart failure[1].

体内研究
(In Vivo)

R9-13 (0.9-30 nmol/kg (30 μg/kg)；单剂量) 在经雌激素预处理的 CD1 雌性小鼠中呈现出剂量依赖性的持续性耻骨韧带延长 (PLE) 效应，ED50 为 5 nmol/kg[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CD1 (female; estrogen-primed)[1]
Dosage: 0.9, 3.0, 9, 30 nmol/kg; 1, 10, 30 nmol/kg
Administration: single dose; measured at 168 h after treatment
Result: Observed dose-responsive pubic ligament elongation at 24 hours post-dosing; sustained elongation effect at 168 hours post-dosing.
分子量

6722.00

Formula

C294H478N78O83S9
Sequence

Chain1:{pGln}-Cys(carbamic acid-PEG2-carbamic acid-PEG2-Lys-C18diacid)-Tyr-Ser-Ala-Leu-Ala-Asn-Lys-Cys-Cys-His-Val-Gly-Cys-Ile-Lys-Arg-Ser-Leu-Ala-Arg-Phe-Cys; Chain2:Ala-Ser-Trp-Met-Glu-Glu-Val-Ile-Lys-Leu-Cys-Gly-Arg-Glu-Leu-Val-Arg-Ala-Gln-Ile-Ala-Ile-Cys-Gly-Met-Ser-Thr-Trp-Ser (Disulfidebridge:Chain 1 Cys10-Chain 1 Cys15,Chain 1 Cys11-Chain 2 Cys11,Chain 1 Cys24-Chain 2 Cys23
Sequence Shortening

Chain1:{pGln}-Cys(carbamic acid-PEG2-carbamic acid-PEG2-Lys-C18diacid)-YSALANKCCHVGCIKRSLARFC; Chain2:ASWMEEVIKLCGRELVRAQIAICGMSTWS (Disulfidebridge:Chain 1 Cys10-Chain 1 Cys15,Chain 1 Cys11-Chain 2 Cys11,Chain 1 Cys24-Chain 2 Cys23
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

R9-13 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

R9-13RXFP ReceptorRelaxin family peptideacute heart failureLGR7 (RXFP1)pubic ligamentrodentsCD1 female micecyclic AMP response element-driven luciferase reporter assayestrogen-primed miceLGR7-overexpressing HEK-293 cellsrelaxin-2Inhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
R9-13
目录号：
HY-P11625
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z