2. Cell Cycle/DNA Damage Stem Cell/Wnt Cytoskeleton TGF-beta/Smad
  3. ROCK β-catenin Collagen
  4. SB772077B

SB772077B 是一种 ROCK 抑制剂。SB772077B 具有抗炎活性，可通过抑制 RhoA/ROCK 信号通路来增强房水流出率 (OF)。SB772077B 可显著降低 β-catenin 的 mRNA 水平以及纤维化标志物 (如 vinculin、fibronectin、collagen 1 A 和 vimentin) 的蛋白水平。SB772077B 还具有血管舒张活性，可降低肺动脉和全身血压。SB772077B 可用于青光眼和肺动脉高压疾病的研究。

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SB772077B

SB772077B Chemical Structure

CAS No. : 785774-34-7

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规格 是否有货
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SB772077B 的其他形式现货产品:

Customer Review

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SB772077B 相关抗体

Top Publications Citing Use of Products

查看 ROCK 亚型特异性产品:

查看所有亚型
ROCK ROCK1 ROCK2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SB772077B is a ROCK inhibitor. SB772077B has an anti-inflammatory activity and enhances aqueous outflow facility (OF) by inactivating RhoA/ROCK signal pathway. SB772077B significantly reduces the mRNA level of β-catenin and protein level of fibrotic markers, such as vinculin, fibronectin, collagen 1 A and vimentin. SB772077B also has vasodialatory activity and decreases pulmonary and systemic blood pressure. SB772077B can be used for glaucoma research and pulmonary hypertensive disorder research[1][2].

IC50 & Target[1]

Collagen I

 

分子量

342.36

Formula

C15H18N8O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SB772077B 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SB772077B785774-34-7ROCKβ-cateninCollagenRho-associated protein kinaseRho-associated kinaseRho-kinaseROKBeta cateninHTM cellsaqueous outflow facilityRhoA/ROCKanti-inflammatoryvasodialatoryglaucomapulmonary hypertensive disorderInhibitorinhibitorinhibit

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