1. 一站式药筛
  2. 化合物库
  3. 片段化合物库系列
  4. 功能性片段库
  5. 高溶解性片段库
高溶解性片段库 - Fragment Library with Good Solubility

Cat. No.: HY-L929

在药物研发领域,靶点结合与成药属性优化是核心环节,而高溶解度是药物成药的关键属性之一,直接影响药物研发的进程。良好的溶解度可保障药物分子在体内快速溶解、均匀分布,进而提升生物利用度,有效规避因溶解度不足导致的药效不佳、给药剂量增加或毒副作用增强等问题。

从药物分子设计角度出发,高溶解度药物片段既是优质的“分子砌块”,也基于这些片段可快速筛选出具有潜在成药价值的先导化合物,能够显著缩短药物研发周期、降低研发成本。同时高溶解度药物片段库能为不同治疗领域的药物研发提供多样化选择,针对临床现有药物的溶解度缺陷提供解决方案,助力开发出生物利用度更高、安全性更好的新型高效靶向药物。

MCE收集整理了将近3000个经过实验验证的高溶解性的小分子片段,可直接为药物分子设计提供经过预先的溶解度验证的优质片段,显著提升先导化合物筛选效率,可加速推进药物研发进程。

  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
- +

Compound Screening Libraries

Top Publications Citing Use of MCE Products

MCE 顾客使用化合物库产品发表的文献

  • 生物活性
  • 产品详情

活性描述 & 特点

Biological Activity

•    A unique collection of 3,000 compounds can be used for the scaffold design and activity screening of subsequent drug molecules.

•    It is obtained through experimentally validated screening for high-solubility compound fragments.

•    All compounds are available off the shelf.

•    All compounds are validated by LC-MS or NMR to ensure high purity and quality.

产品详情

Product Details

Formulation:

A compound library with experimentally validated high solubility can be used for the scaffold design and activity screening of subsequent drug molecules.

Layout:

96-well storage tube or 96-well plate: 1st and 12th column are left empty.
384-well plate: the first two columns and the last two columns are left empty.
Compounds with different concentrations or dissolved in different solvents will be put on separate plates. This way of layout may increase the number of plates because there could be three solvents and three concentrations.
If you have other requirements, please let us know.

Container:

96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode.

Storage:

-80°C

Shipping:

Blue ice or dry ice

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  •  特定化合物
  •  化合物数量
  •  产品排布图
  •  浓度
  •  形式(固体或溶液)
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联系专家定制
  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack

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    产品名称:
    Fragment Library with Good Solubility
    目录号:
    HY-L929
    需求量: