AMP-PNP (Adenylyl imidodiphosphate) 是一种非水解的 ATP 类似物。AMP-PNP 能够竞争性结合 ATP 结合位点，但不会被酶水解，从而在研究 ATP 依赖的过程中提供了稳定的实验条件。AMP-PNP 还可用于酶活性、激酶调控、DNA/RNA 代谢、离子通道功能以及蛋白质复合物组装等研究。
AMP-PNP (Adenylyl-imidodiphosphate) tetralithium 是一种非水解的 ATP 类似物。AMP-PNP tetralithium 能够竞争性结合 ATP 结合位点，但不会被酶水解，从而在研究 ATP 依赖的过程中提供了稳定的实验条件。AMP-PNP tetralithium 还可用于酶活性、激酶调控、DNA/RNA 代谢、离子通道功能以及蛋白质复合物组装等研究。
A sub-library of GPCR Library designed for the discovery of novel allosteric ligands. Allosteric GPCRs Library is a utile starting point for the drug discovery in the field of allosteric GPCR modulators.
The Chinese National Compound Library (CNCL) composes 1.4 million compounds possessing diversified structures. Coupled with this library will be advanced sample handling, information management and quality control systems. Most compounds in the library are drug-like, conforming to “Lipinski’s Rule of Five”, such as MW < 500, logP < 5, Hydrogen Bond Donors < 5.
A unique collection of 47,360 novel small molecules with high CNS MPO (Central Nervous System Multiparameter Optimization) scores. The CNS-active molecules which are able to penetrate blood-brain barrier (BBB) were low polar surface area, low degree of possible hydrogen bond formation and low ClogP values.
ASINEX has elaborated a library of diverse macrocycles using an effective tool box of synthetic methods. The resulting scaffolds are novel, tremendously diverse, medchem-relevant, macrocyclic frameworks.
Macrocyles tend to be larger than traditional screening molecules which make them perfect discovery tools for targets with shallow or extended binding sites. At the same time, their unique character based on restricted flexibility and ability to form intra-molecular hydrogen bonds allows for design approaches effectively optimizing properties such asaqueous solubility and membrane permeability. Many of these macrocycles have been tested for aqueous and DMSO solubility with cut-offs applied at 10 mM in DMSO and 50 µM in PBS (pH 7.4) followed by PAMPA permeability assay.
MCE 3D 多样片段库由 5,400 个非平面片段分子组成（平均 Fsp3 值为 0.58），超过4,700个片段至少包含一个手性中心。本库设计的关键元素是 3D 结构、多样性、生物反应性等。另，库中化合物在保证高sp3中心和 3D 结构优势的同时，还有效提高了片段潜在生物活性，为基于片段的药物发现提供了更高的片段命中优化概率，增加了找到创新命中的可能性。
2024年5月，Nature杂志在线发表了题为“Dimerization and antidepressant recognition at noradrenaline transporter”的研究论文，该研究成果由中国科学院上海药物研究所完成。该研究破解了重要神经系统疾病靶标——去甲肾上腺素转运体（NET），获得了人源NET同源二聚体分别与转运天然底物去甲肾上腺素NE，以及六种选择性抗抑郁药物的结合模式，为理解NET等单胺类转运体的生理调控机制奠定了重要的理论基础。
Natural products are an attractive source with varied structures that exhibit potent biological activities, and desirable pharmacological profiles. The core scaffold of a natural product can also provide a biologically validated framework upon which to display diverse functional groups. Inspired by bioactive natural products, natural product-like compounds, occupying the same chemical space, are ideally suited to explore and to facilitate understanding of biological pathways.
MCE 10K Natural Product-like Compound Library consists of 10,000 natural product-like compounds. Each compound has scaffold of natural products or Tanimoto coefficient >0.6 with natural products. The natural-likeness scoring of these compounds is >-2. What’s more, compounds in the library are drug-like and readily available for re-supply, making it a powerful tool for new drug research and development. It can be widely applied in high-throughput screening (HTS) and high-content screening (HCS).
MCE Drug Fragment Library 由 1,168 个药物片段组成。这些药物片段来自 2,946 个 FDA 已批准的药物分子。同一药物的不同片段可以出现在其他药物中，这些片段和 PK/PD 性质存在一定的相关性，基于片段的筛选可以为后续优化结构预留出足够的化学空间。该化合物库是 FBDD（基于片段的药物设计）药物筛选的必备工具。
AMP-PNP (Adenylyl imidodiphosphate) 是一种非水解的 ATP 类似物。AMP-PNP 能够竞争性结合 ATP 结合位点，但不会被酶水解，从而在研究 ATP 依赖的过程中提供了稳定的实验条件。AMP-PNP 还可用于酶活性、激酶调控、DNA/RNA 代谢、离子通道功能以及蛋白质复合物组装等研究。
ABC 29; ABC29; ABCC 1; ABCC; Abcc1; ATP binding cassette sub family C CFTR/MRP; member 1; ATP binding cassette sub-family C member 1; ATP binding cassette subfamily C member 1; ATP binding cassette transporter variant ABCC1delta ex13; ATP binding cassette transporter variant ABCC1delta ex13&14; ATP binding cassette transporter variant ABCC1delta ex25; ATP binding cassette transporter variant ABCC1delta ex25&26; ATP binding cassette, sub-family C CFTR/MRP; , member 1; ATP-binding cassette sub-family C member 1; DKFZp686N04233; DKFZp781G125; GS X; GSX; Leukotriene C4; transporter; LTC4 transporter; MRP 1; MRP; MRP1; MRP1_HUMAN; Multidrug resistance associated protein 1; Multidrug resistance protein; Multidrug resistance-associated protein 1; Multiple drug resistance associated protein; Multiple drug resistance protein 1
PAK4; p21 protein (Cdc42/Rac)-activated kinase 4; p21(CDKN1A) activated kinase 4; serine/threonine-protein kinase PAK 4; PAK-4; p21-activated kinase 4; p21(CDKN1A)-activated kinase 4; protein kinase related to S. cerevisiae STE20, effector for Cdc42Hs
MRP4; MOATB; MOAT-B; EST170205; ABCC 4 antibody;
ABCC4 antibody;
ATP binding cassette sub family C (CFTR/MRP) member 4 antibody;
ATP binding cassette sub family C member 4 antibody
ABC42 antibody; Abcd1 antibody; ABCD1_HUMAN antibody; Adrenoleukodystrophy protein antibody; ALD antibody; Aldgh antibody; ALDP antibody; AMN antibody; ATP binding cassette, sub family D (ALD), member 1 antibody; ATP-binding cassette sub-family D member 1 antibody; ABC42 antibody; Abcd1 antibody; ABCD1_HUMAN antibody; Adrenoleukodystrophy protein antibody; ALD antibody; Aldgh antibody; ALDP antibody; AMN antibody; ATP binding cassette, sub family D (ALD), member 1 antibody; ATP-binding cassette sub-family D member 1 antibody; OTTHUMP00000025960 antibody; OTTMUSP00000019283 antibody; RGD1562128 antibody; RP23 373N8.2 antibody; X linked adrenoleukodystrophy (ALD) gene homolog antibody;
NCOA3; AIB1; BHLHE42; Rac3; TRAM1; Nuclear receptor coactivator 3; NCoA-3; ACTR; amplified in breast cancer 1 protein; AIB-1; CBP-inteRacting protein; pCIP; Class E basic helix-loop-helix protein 42; bHLHe42; Receptor-associated coactivator
ABC20; ABCB1; ATP binding cassette, sub family B(MDR/TAP), member 1; ATP-binding cassette sub-family B member 1; CD243; CLCS; Colchicin sensitivity; Doxorubicin resistance; GP170; MDR1; MDR1_HUMAN; Multidrug resistance 1; Multidrug resistance protein 1; P glycoprotein 1; P gp; PGY1.
IHC-P, IF-Tissue, IHC-F, WB
Human, Mouse, Rat
P Glycoprotein Antibody (YA6354) 是一个兔来源、无偶联标记、抗 P Glycoprotein 的 IgG 单克隆抗体。
ABC20; ABCB1; ATP binding cassette, sub family B; MDR/TAP; , member 1; ATP-binding cassette sub-family B member 1; CD243; CLCS; Colchicin sensitivity; Doxorubicin resistance; GP170; MDR1; MDR1_HUMAN; Multidrug resistance 1; Multidrug resistance protein 1; P glycoprotein 1; P gp; P-glycoprotein 1; PGY1
IHC-P, WB, ICC/IF, ELISA
Human, Mouse,
P Glycoprotein Antibody (YA5626) 是一个小鼠来源、无偶联标记、抗 P Glycoprotein 的 IgG1 单克隆抗体。
ABC20; ABCB1; ATP binding cassette, sub family B; MDR/TAP; , member 1; ATP-binding cassette sub-family B member 1; CD243; CLCS; Colchicin sensitivity; Doxorubicin resistance; GP170; MDR1; MDR1_HUMAN; Multidrug resistance 1; Multidrug resistance protein 1; P glycoprotein 1; P gp; P-glycoprotein 1; PGY1
IHC-P, ELISA
Human, Mouse,
P Glycoprotein Antibody (YA5747) 是一个小鼠来源、无偶联标记、抗 P Glycoprotein 的 IgG1 单克隆抗体。
ABC20; ABCB1; ATP binding cassette, sub family B; MDR/TAP; , member 1; ATP-binding cassette sub-family B member 1; CD243; CLCS; Colchicin sensitivity; Doxorubicin resistance; GP170; MDR1; MDR1_HUMAN; Multidrug resistance 1; Multidrug resistance protein 1; P glycoprotein 1; P gp; P-glycoprotein 1; PGY1
WB, IHC-P, ICC/IF, IP, ELISA
Human
P Glycoprotein Antibody (YA6028) 是一个兔来源、无偶联标记、抗 P Glycoprotein 的 IgG 单克隆抗体。
