2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. Calcium Channel
  4. SERCA2a activator 2

SERCA2a activator 2 (Compound 25) 是一种强效的 SERCA2a (心脏型) 激活剂，其对 SERCA1a (骨骼肌型) 也具有激活作用。SERCA2a activator 2 在 [Ca²⁺]MAX 条件下其激活 SERCA2a 的 ATP 酶活性并促进 Ca²⁺ 摄取，其 EC₅₀ 分别为 4 μM 和 0.80 μM。SERCA2a activator 2 在更接近生理状态的 [Ca²⁺]MID 条件下也表现出一致的激活作用。SERCA2a activator 2 具有低细胞毒性，可用于研究心力衰竭等疾病。

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SERCA2a activator 2

SERCA2a activator 2 Chemical Structure

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SERCA2a activator 2 相关抗体

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N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SERCA2a activator 2 (Compound 25) is a potent SERCA2a (cardiac type) activator, which also has an activating effect on SERCA1a (skeletal muscle type). SERCA2a activator 2, under [Ca²⁺]MAX conditions activates the ATPase activity of SERCA2a and promotes Ca²⁺ uptake, with its EC₅₀ values being 4 μM and 0.80 μM respectively. SERCA2a activator 2 also exhibits consistent activating effects under more physiological [Ca²⁺]MID conditions. SERCA2a activator 2 has low cytotoxicity and can be used for research on diseases such as heart failure[1].

分子量

380.25

Formula

C18H19BrFNO2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SERCA2a activator 2 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SERCA2a activator 2Calcium ChannelCa2+ channelsCa channelsSERCA2aATPase activitySARActivatorsCalcium uptakeADMETHeart failureInhibitorinhibitorinhibit

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