2. Metabolic Enzyme/Protease
  3. Xanthine Oxidase
  4. Smilaxchinoside A

Smilaxchinoside A 是一种具有口服活性的甾体糖苷，被发现存在于 S. riparia 的根中。Smilaxchinoside A 可降低血清尿酸水平，并表现出强效的促尿酸排泄活性。Smilaxchinoside A 可抑制黄嘌呤氧化酶 (XOD) 活性，同时下调肾脏 mURAT1 的表达。Smilaxchinoside A 可用于高尿酸血症的研究。

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Smilaxchinoside A

Smilaxchinoside A Chemical Structure

CAS No. : 935530-84-0

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Smilaxchinoside A 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Smilaxchinoside A is an orally active steroidal glycoside found in the roots of S. riparia. Smilaxchinoside A reduces serum uric acid levels and shows potent uricosuric activity. Smilaxchinoside A inhibits XOD activity and downregulates renal mURAT1 expression. Smilaxchinoside A can be used for the research of hyperuricemia[1].

体内研究
(In Vivo)

Smilaxchinoside A (10 mg/kg；口服；每天一次；7 天) 通过抑制 XOD 活性并下调肾脏 mURAT1 的表达，在氧酸钾诱导的高尿酸血症小鼠体内发挥显著的降血尿酸和肾脏保护作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Kunming (male, 20 ± 2.0 g, potassium oxonate-induced hyperuricemia)[1]
Dosage: 10 mg/kg
Administration: P.o.; daily; 7 days
Result: Significantly reduced serum uric acid levels and increased urine uric acid levels compared to the hyperuricemic model group.
Significantly decreased serum creatinine and serum BUN levels compared to the hyperuricemic model group.
Increased urine creatinine levels and the fractional excretion of uric acid compared to the hyperuricemic model group.
Significantly reduced serum and liver xanthine oxidase (XOD) activities compared to the hyperuricemic model group.
Significantly down-regulated renal mURAT1 protein expression compared to the hyperuricemic model group.
Showed no significant effects on renal mGLUT9 or mOAT1 protein levels compared to the hyperuricemic model group.
分子量

1047.18

Formula

C51H82O22
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Smilaxchinoside A 相关分类

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Keywords:

Smilaxchinoside A935530-84-0Xanthine OxidaseXOXODxanthine oxidasemouse Urate Transporter 1mURAT1hyperuricemicrenal dysfunctionInhibitorinhibitorinhibit

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