2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. Calcium Channel
  4. Sulofenur

Sulofenur (Diarylsulfonylurea; LY186641) 是一种口服有效的抗肿瘤剂。Sulofenur 通过钙离子依赖途径和部分蛋白激酶非依赖途径诱导基因表达，尤其在 H-ras 突变细胞中作用增强。Sulofenur 对小鼠实体瘤模型和人类肿瘤异种移植模型具有显著活性。

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Sulofenur

Sulofenur Chemical Structure

CAS No. : 110311-27-8

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Sulofenur 相关抗体

Top Publications Citing Use of Products

查看 Calcium Channel 亚型特异性产品:

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N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Sulofenur (Diarylsulfonylurea; LY186641) is an orally active anti-tumor agent. Sulofenur induces gene expression through calcium ion-dependent pathways and some protein kinase-independent pathways, and its effect is particularly enhanced in H-ras mutant cells. Sulofenur exhibits significant activity in mouse solid tumor models and human tumor xenograft models[1][2][3].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
11.34 μM
Compound: LY-186641
In vitro cytotoxic activity against human lung carcinoma A549 cell line
In vitro cytotoxic activity against human lung carcinoma A549 cell line
10.1016/0960-894X(96)00463-5
A549 IC50
36.43 μM
Compound: 2
Cytotoxicity against human lung carcinoma A549 cell line using MTT assay
Cytotoxicity against human lung carcinoma A549 cell line using MTT assay
[PMID: 9873387]
A549 IC50
> 20 μM
Compound: Sulofenur
Anticancer activity against human A549 cells by MTT assay
Anticancer activity against human A549 cells by MTT assay
[PMID: 21570750]
CCRF-CEM IC50
11.2 μg/mL
Compound: 104 (LY-186641)
Concentration required to inhibit growth of CCRF-CEM cells in culture for 72 hr to 50% of control growth
Concentration required to inhibit growth of CCRF-CEM cells in culture for 72 hr to 50% of control growth
[PMID: 2391684]
CCRF-CEM IC50
11.2 μg/mL
Compound: Sulofenur
In vitro cytotoxicity against CCRF-CEM cells
In vitro cytotoxicity against CCRF-CEM cells
[PMID: 9083492]
CCRF-CEM IC50
32 μM
Compound: Sulofenur
Cytotoxicity against CCRF-CEM lymphocytic leukemia cell line
Cytotoxicity against CCRF-CEM lymphocytic leukemia cell line
[PMID: 10476861]
COLO 205 IC50
23.06 μM
Compound: Sulofenur
Anticancer activity against human COLO205 cells by MTT assay
Anticancer activity against human COLO205 cells by MTT assay
[PMID: 21570750]
K562 IC50
19.2 μM
Compound: Sulofenur
Anticancer activity against human K562 cells by MTT assay
Anticancer activity against human K562 cells by MTT assay
[PMID: 21570750]
K562 IC50
50.08 μM
Compound: 2
Cytotoxicity against human chronic myelogenous leukemia (K562) cell line using MTT assay
Cytotoxicity against human chronic myelogenous leukemia (K562) cell line using MTT assay
[PMID: 9873387]
P388D1 IC50
> 100 μM
Compound: Sulofenur
Anticancer activity against mouse P388D1 cells by MTT assay
Anticancer activity against mouse P388D1 cells by MTT assay
[PMID: 21570750]
SK-MEL-2 IC50
12.91 μM
Compound: LY-186641
In vitro cytotoxic activity against human melanoma SK-MEL-2 cell line
In vitro cytotoxic activity against human melanoma SK-MEL-2 cell line
10.1016/0960-894X(96)00463-5
SK-OV-3 IC50
222.9 μM
Compound: 2
Cytotoxicity against human ovarian adenocarcinoma (SK-OV-3) cell line using MTT assay
Cytotoxicity against human ovarian adenocarcinoma (SK-OV-3) cell line using MTT assay
[PMID: 9873387]
SK-OV-3 IC50
78.2 μM
Compound: Sulofenur
Anticancer activity against human SKOV3 cells by MTT assay
Anticancer activity against human SKOV3 cells by MTT assay
[PMID: 21570750]
分子量

350.82

Formula

C16H15ClN2O3S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Sulofenur 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sulofenur110311-27-8Diarylsulfonylurea LY186641LY186641LY 186641LY-186641Calcium ChannelCa2+ channelsCa channelsCytosolic Ca2+H-rasKidney cellsProtein kinasesc-fosc-junhsp70Inhibitorinhibitorinhibit

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