2. Protein Tyrosine Kinase/RTK Cell Cycle/DNA Damage Autophagy Apoptosis
  3. PDGFR VEGFR IRE1 Mitophagy Autophagy Apoptosis
  4. Sunitinib glucuronate

Sunitinib glucuronate  (Synonyms: SU 11248 glucuronate)

目录号: HY-10255C
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Sunitinib (SU 11248) glucuronate 是一种多靶点受体酪氨酸激酶抑制剂，抑制 VEGFR2 和 PDGFRβ 的 IC50 分别为 80 nM 和 2 nM。Sunitinib glucuronate 是 ATP 竞争性抑制剂，可通过抑制自身磷酸化和随后的 RNase 激活来有效抑制 Ire1α 的磷酸化。

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CAS No. : 1818285-48-1

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10 mg ￥1250
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25 mg ￥2500
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50 mg ￥4000
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Other Forms of Sunitinib glucuronate:

Sunitinib glucuronate 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 86 篇科研文献

WB
RT-PCR
IHC
Cell Proliferation/Viability Assay
IF

    Sunitinib glucuronate purchased from MCE. Usage Cited in: Theranostics. 2018 Jul 30;8(15):4262-4278.  [Abstract]

    BV2 cells are pretreated with 0.1% DMSO (Ctrl), JuA (25 µM) or JuA (25 µM) with the indicated antagonist of RTKs (Dovitinib at 1 µM, Gefinitib at 2.5 µM, Sunitinib at 2.5 µM and LDC1267 at 1 µM) for 30 min, followed by administration of Aβ42 (5 μM) for 12 h.

    Sunitinib glucuronate purchased from MCE. Usage Cited in: EBioMedicine. 2018 Nov:37:344-355.  [Abstract]

    Sutent (Sunitinib Malate) treatment decreases lipid accumulation in adipose and liver tissues and increases UCP1 expression in brown adipose tissue. Western blot analysis of UCP1 protein expression level in mouse brown adipose.

    Sunitinib glucuronate purchased from MCE. Usage Cited in: EBioMedicine. 2018 Nov:37:344-355.  [Abstract]

    Sutent (Sunitinib Malate) treatment decreases lipid accumulation in adipose and liver tissues and increases UCP1 expression in brown adipose tissue. Representative images of immunohistochemistry stainining of UCP1 in BAT.

    Sunitinib glucuronate purchased from MCE. Usage Cited in: J Pharm Anal. 2023 May;13(5):514-522.

    Sunitinib (0-100 μM; 72 h) induces significant cell death in T98G cells.

    Sunitinib glucuronate purchased from MCE. Usage Cited in: J Pharm Anal. 2023 May;13(5):514-522.

    Sunitinib (3 μM; 24 h) increases the expression of γ-H2Ax and Temozolomide (TMZ; 10 μM; 24 h) increases the induction of Sunitinib, in T98G cells.

    Sunitinib glucuronate purchased from MCE. Usage Cited in: J Pharm Anal. 2023 May;13(5):514-522.

    Sunitinib (3 μM; 24 h) increases the expression of γ-H2Ax and Temozolomide (TMZ; 10 μM; 24 h) increases the induction of Sunitinib, in T98G cells.

    Sunitinib glucuronate purchased from MCE. Usage Cited in: J Med Chem. 2016 Sep 22;59(18):8456-72.  [Abstract]

    Effect of compounds 1 (Imatinib), 2 (Sunitinib), and 35 on cKIT mediated signaling pathways in GIST-T1 and GIST-5R cancer cell lines.

    Sunitinib glucuronate purchased from MCE. Usage Cited in: Int J Clin Exp Pathol. 2015 Apr 1;8(4):3871-81.  [Abstract]

    The relationship between SOX9 and Raf/MEK/ERK signaling pathway. Co-treatment of si-SOX9-1 and Sorafenib (10uM, 15uM)/Sunitinib (2 uM, 3 uM) significantly decreases expression of MEK1 and its phosphorylated protein (p-MEK1/2, p-ERK1/2) as assayed by Western blot (with GAPDH as internal control).

    Sunitinib glucuronate purchased from MCE. Usage Cited in: Int J Clin Exp Pathol. 2015 Apr 1;8(4):3871-81.  [Abstract]

    The relationship between SOX9 and Raf/MEK/ERK signaling pathway. Co-treatment of si-SOX9-1 and Sorafenib (10uM, 15uM)/Sunitinib (2 uM, 3 uM) significantly decreases expression of MEK1 and its phosphorylated protein (p-MEK1/2, p-ERK1/2) as assayed by RT-PCR (with β-actin as internal control).

    Sunitinib glucuronate purchased from MCE. Usage Cited in: Oncotarget. 2017 Nov 15;8(67):111110-111118.  [Abstract]

    In cell EC50 determination of CHMFL-KIT-031 with parental Colo320DM (KIT wt) and KIT V559D overexpressed Colo320DM cells.

    Sunitinib glucuronate purchased from MCE. Usage Cited in: Oncotarget. 2017 Jul 27;8(56):95116-95134.  [Abstract]

    Abemaciclib causes increased PARP cleavage in RCC. In 786-O cells Abemaciclib exposure results in increased PARP cleavage. This effect is more rapid and pronounced when Abemaciclib is combined with Sunitinib.

    Sunitinib glucuronate purchased from MCE. Usage Cited in: Oncotarget. 2017 Jul 27;8(56):95116-95134.  [Abstract]

    Abemaciclib causes increased PARP cleavage in RCC. In Caki-1 cells Abemaciclib exposure results in increased PARP cleavage. This effect is more rapid and pronounced when Abemaciclib is combined with Sunitinib.

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    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Sunitinib (SU 11248) glucuronate is a multi-targeted receptor tyrosine kinase inhibitor with IC50s of 80 nM and 2 nM for VEGFR2 and PDGFRβ, respectively[1]. Sunitinib glucuronate, an ATP-competitive inhibitor, effectively inhibits autophosphorylation of Ire1α by inhibiting autophosphorylation and consequent RNase activation[2].

    IC50 & Target[1][2]

    VEGFR2

    80 nM (IC50)

    PDGFRβ

    2 nM (IC50)

    IRE1α

     

    分子量

    592.61

    Formula

    C28H37FN4O9
    CAS 号
    性状

    固体

    颜色

    Orange to red

    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式
    Powder -20°C 3 years
    In solvent -80°C 6 months
    -20°C 1 month
    纯度 & 产品资料
    参考文献

    Sunitinib glucuronate 相关分类

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    Keywords:

    Sunitinib glucuronate1818285-48-1SU 11248 glucuronatePDGFRVEGFRIRE1MitophagyAutophagyApoptosisPlatelet-derived growth factor receptorVascular endothelial growth factor receptorInositol requiring enzyme 1Mitochondrial AutophagyInhibitorinhibitorinhibit

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