2. Academic Validation
  3. Fbxo45 promotes cell viability, invasion and sunitinib resistance of clear cell renal cell carcinoma by targeting Erbin

Fbxo45 promotes cell viability, invasion and sunitinib resistance of clear cell renal cell carcinoma by targeting Erbin

  • Exp Cell Res. 2026 Jan 15;454(2):114839. doi: 10.1016/j.yexcr.2025.114839.
Xueshan Pan 1,  Ke Yu 2,  Kai Chen 3,  Jiao Wang 3,  Zheng Huang 3,  Jiewen Wang 4,  Tong Cao 5,  Jia Ma 6
Affiliations

Affiliations

  • 1 Bengbu Medical University Key Laboratory of Cancer Research and Clinical Laboratory Diagnosis, Bengbu Medical University, Anhui, 233030, China; Department of Biochemistry and Molecular Biology, School of Laboratory Medicine, Bengbu Medical University, Anhui, 233030, China; Anhui Provincial Key Laboratory of Tumor Evolution and Intelligent Diagnosis and Treatment, China.
  • 2 Bengbu Medical University Key Laboratory of Cancer Research and Clinical Laboratory Diagnosis, Bengbu Medical University, Anhui, 233030, China; Department of Clinical Laboratory, Wuxi Huishan District People's Hospital, Jiangsu, 214100, China.
  • 3 Bengbu Medical University Key Laboratory of Cancer Research and Clinical Laboratory Diagnosis, Bengbu Medical University, Anhui, 233030, China.
  • 4 Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Bengbu Medical University, Bengbu, 233004, Anhui, China.
  • 5 Department of Clinical Laboratory, The First Affiliated Hospital of Bengbu Medical University, Bengbu, 233004, Anhui, China. Electronic address: caotong1027@163.com.
  • 6 Bengbu Medical University Key Laboratory of Cancer Research and Clinical Laboratory Diagnosis, Bengbu Medical University, Anhui, 233030, China; Department of Biochemistry and Molecular Biology, School of Laboratory Medicine, Bengbu Medical University, Anhui, 233030, China. Electronic address: majiamj@bbmc.edu.cn.
PMID: 41285235 DOI: 10.1016/j.yexcr.2025.114839
Abstract

The mechanisms underlying the development and progression of clear cell renal cell carcinoma (ccRCC) and its sunitinib resistance are elusive. Fbxo45 is a member of the F-box protein family that has been demonstrated to participate in tumorigenesis. However, the role of Fbxo45 in ccRCC progression has not been characterized. This study aims to investigate the biological functions and molecular mechanism of Fbxo45 in ccRCC progression. We found that Fbxo45 knockdown inhibited the viability and motility of ccRCC cells, while Fbxo45 overexpression resulted in the opposite phenotype. Ectopic expression of Fbxo45 promoted tumor growth in mice. Fbxo45 expression was negatively correlated with Erbin expression, which has been reported to mediate anti-tumor activities in ccRCC. Furthermore, Fbxo45 facilitated ccRCC cell viability and motility by inhibiting Erbin. Notably, Fbxo45 upregulation reduced sunitinib sensitivity in ccRCC cells. Our results suggest that Fbxo45 could be a potential target for ccRCC treatment and sunitinib resistance.

Keywords

Erbin; Fbxo45; Invasion; Kidney cancer; Ubiquitination.

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