2. Cell Cycle/DNA Damage Epigenetics Immunology/Inflammation
  3. PARP IFNAR
  4. TIPARP-IN-1

TIPARP-IN-1 (Compound 15) 是一种选择性的 PARP7 (TIPARP，即 2,3,7,8 - 四氯二苯并-p-二恶英 (TCDD) 诱导型 PARP) 抑制剂，其 IC50 值为 2.15 nM。TIPARP-IN-1 可通过抑制 TIPARP 来恢复肿瘤中的 IFN 信号通路。TIPARP-IN-1 能选择性激活肿瘤微环境中的抗肿瘤免疫反应，并避免全身性细胞因子的产生。TIPARP-IN-1 可用于头颈部鳞状细胞癌的研究。

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TIPARP-IN-1

TIPARP-IN-1 Chemical Structure

CAS No. : 3106183-96-1

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TIPARP-IN-1 相关抗体

Top Publications Citing Use of Products

查看 PARP 亚型特异性产品:

查看所有亚型
PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TIPARP-IN-1 (Compound 15) is a selective PARP7 (TIPARP) (2,3,7,8-Tetrachlorodiben-zo-p-dioxin(TCDD)-inducible PARP) inhibitor with an IC50 of 2.15 nM. TIPARP-IN-1 can restore IFN signaling pathway in tumors by inhibiting TIPARP. TIPARP-IN-1 selectively activates the anti-tumor immune response in the tumor microenvironment and avoids the production of systemic cytokines. TIPARP-IN-1 can be used for research of head and neck squamous cell carcinoma[1].

IC50 & Target[1]

PARP7

2.15 nM (IC50)

分子量

503.44

Formula

C22H23F6N5O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TIPARP-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TIPARP-IN-13106183-96-1PARPIFNARpoly ADP ribose polymerase Interferon-α/β receptorInterferon-alpha/beta receptorInhibitorinhibitorinhibit

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