2. PROTAC Immunology/Inflammation Epigenetics
  3. PROTACs Asialoglycoprotein Receptor (ASGPR) Epigenetic Reader Domain
  4. TMU454

TMU454 是一种 prototype GalNAc-PROTAC 偶联物。TMU454 与细胞膜上的 ASGPR 结合，然后通过 ASGPR 介导的内吞作用被内化。TMU454 选择性降解 BRD4。TMU454 对肝细胞癌具有抗癌活性。

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TMU454

TMU454 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

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Customer Review

TMU454 相关抗体

Top Publications Citing Use of Products

查看 PROTACs 亚型特异性产品:

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TMU454 is a prototype GalNAc-PROTAC conjugate. TMU454 binds to ASGPR on the membrane of cells, and then is internalized via ASGPR-mediated endocytosis. TMU454 selectively degrades BRD4. TMU454 exhibits anticancer activity against hepatocellular carcinoma[1].

IC50 & Target[1]

BRD4

 

分子量

3102.96

Formula

C142H214ClN27O44S2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TMU454 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TMU454TMU 454TMU-454PROTACsAsialoglycoprotein Receptor (ASGPR)Epigenetic Reader DomainAsialoglycoprotein ReceptorAshwell-Morell ReceptorInhibitorinhibitorinhibit

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产品名称：
TMU454
目录号：
HY-180909
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