2. Cell Cycle/DNA Damage Cytoskeleton
  3. Mps1
  4. TTK-IN-5

TTK-IN-5 是一种口服有效、有选择性的共价苏氨酸酪氨酸激酶 (TTK) 抑制剂 (IC50 = 8.918 nM)。TTK-IN-5 对 MDA-MB-231、A2780、HCT116、HCC1569 和 MKN1 细胞系均表现出抗增殖活性，IC50 值分别为 0.113 μM、0.476 μM、3.136 μM、3.649 μM 和 1.856 μM。在 A2780 和 MDA-MB-231 异种移植小鼠模型中，TTK-IN-5 能有效抑制肿瘤生长且无明显毒性。TTK-IN-5 可用于乳腺癌和卵巢癌等癌症的研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

TTK-IN-5

TTK-IN-5 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

TTK-IN-5 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TTK-IN-5 is an orally active covalent threonine tyrosine kinase (TTK) inhibitor with selectivity (IC50 = 8.918 nM). TTK-IN-5 exhibits anti-proliferative potencies against MDA-MB-231, A2780, HCT116, HCC1569 and MKN1 cell lines (IC50 values of 0.113 μM, 0.476 μM, 3.136 μM, 3.649 μM, and 1.856 μM, respectively). TTK-IN-5 potently suppresses tumor growth without notable toxicity in A2780 and MDA-MB-231 xenograft mouse models. TTK-IN-5 can be used for the research of cancer such as breast cancer and ovarian cancer[1].

体外研究
(In Vitro)

TTK-IN-5 (Compound 19) (1 μM) 对苏氨酸酪氨酸激酶 (TTK) 具有强效且高度选择性的抑制活性，抑制率高达 98.99% (IC50 = 8.918 nM)[1]。
TTK-IN-5 (5 μM, 12 小时) 与 TTK 形成强效相互作用并紧密结合[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

TTK-IN-5 相关抗体:
体内研究
(In Vivo)

TTK-IN-5 (Compound 19) (7.5, 15 mg/kg, 静脉注射, 每周两次, 持续 21 天) 在 MDA-MB-231 异种移植小鼠模型中能显著抑制肿瘤生长，且毒性较低[1]。
TTK-IN-5 (30 mg/kg, 口服, 每日一次, 持续 21 天) 在 A2780 异种移植小鼠模型中能抑制肿瘤生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MDA-MB-231 xenograft mouse model in female BALB/c nude mice (6-8 weeks)[1]
Dosage: 7.5, 15 mg/kg, Paclitaxel (HY-B0015) 10 mg/kg
Administration: Intravenous injection (i.v.), twice a week for 21 days
Result: Showed tumor growth inhibition (TGI) values of 49.3% and 66.0% at doses of 7.5 mg/kg and 15 mg/kg, respectively.
Markedly suppressed tumor growth (TGI = 75.0%), with no significant changes in animal body weights following combination treatment of Paclitaxel.
Inhibited tumor cell proliferation and markedly induced cell death when co-administrated with Paclitaxel.
Decreased phosphorylation of TTK in a dose dependent manner.
Increased Bax protein levels and suppressed Bcl-2 protein, explaining its apoptotic potency.
Animal Model: A2780 xenograft mouse model in female BALB/c nude mice (6-8 weeks)[1]
Dosage: 30 mg/kg
Administration: oral administration (p.o.), once daily for 21 days
Result: Effectively inhibited tumor growth, reaching the tumor growth inhibition (TGI) of 36.46%.
Significantly inhibited tumor volume.
Induced no significant changes in body weight.
分子量

533.53

Formula

C28H25F2N5O4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TTK-IN-5 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TTK-IN-5Mps1Monopolar spindle 1Threonine tyrosine kinase (TTK)Kinase inhibitorA2780MDA-MB-231covalentcancerInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
TTK-IN-5
目录号：
HY-179430
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z