2. Membrane Transporter/Ion Channel Neuronal Signaling Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. GABA Receptor Reactive Oxygen Species (ROS)
  4. Umbelopsisin A

Umbelopsisin A 是一种非选择性 GABAA 和 GABAB 受体激动剂。Umbelopsisin A 可激活 GABA 能通路，包括 Notch 信号通路和脂肪酸代谢。Umbelopsisin A 在体外 (减少活性氧 (ROS) 和细胞死亡) 和体内均表现出对谷氨酸兴奋性毒性的双重神经保护作用。Umbelopsisin A 可用于青光眼及其他神经退行性疾病的研究。

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Umbelopsisin A

Umbelopsisin A Chemical Structure

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Umbelopsisin A 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Umbelopsisin A is a GABAA and GABAB non-selective agonist. Umbelopsisin A activates the GABAergic pathway, including notch signaling and fatty acid metabolism. Umbelopsisin A shows dual neuroprotection against glutamate excitotoxicity in vitro (reducing ROS and cell death) and in vivo. Umbelopsisin A can be used for the study of glaucoma and broader neurodegenerative disease applications[1].

体外研究
(In Vitro)

Umbelopsisin A (0.5 μM-16 μM; 24 h; R28 细胞) 拯救 R28 细胞免受 Glu 引起的兴奋性毒性并减少 ROS 产生[1]。
Umbelopsisin A (2 μM；24 小时；R28 细胞) 调节 R28 细胞中的基因表达，促进轴突发生和 GABA 相关通路[1]。
Umbelopsisin A (20 μM-400 μM；24 小时；R28 细胞) 作为 GABA 受体激动剂，直接与 GABA_A 和 GABA_B 受体结合[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Umbelopsisin A 相关抗体:

Cell Viability Assay[1]

Cell Line: R28 cells
Concentration: 0.5 μM, 1 μM, 2 μM, 3 μM, 4 μM, 8 μM, 16 μM
Incubation Time: 24 h
Result: Partially restored glutamate (Glu)-induced cell viability reduction.
Significantly reduced Glu-induced R28 cell death and ROS production, with 2 μM showing significant protection.
At 16 μM, significantly reduced cell viability compared to the Glu group.
体内研究
(In Vivo)

Umbelopsisin A (20 μM; 玻璃体内; 1 μL) 在 NMDA 诱导的 C57BL/6 小鼠视网膜损伤中保护视网膜神经节细胞 (RGC) 并改善视觉功能[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 (male, 8 weeks) bearing NMDA-induced retinal injury[1]
Dosage: 20 μM
Administration: Intravitreal; 1 μL
Result: RGCs density was significantly preserved in the central and mid-peripheral retina. NMDA-induced GCC thinning was significantly attenuated. f-ERG and f-VEP wave amplitudes were significantly improved.
分子量

365.38

Formula

C21H19NO5
结构分类
初始来源

Umbelopsis sp. DWS 372
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Umbelopsisin A 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

Umbelopsisin AGABA ReceptorReactive Oxygen Species (ROS)Gamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorGABA and GABA receptor antagonistsGABA and GABA receptor affinitiesGABA receptor agonistGABAergic modulationInhibitorinhibitorinhibit

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