2. Cell Cycle/DNA Damage
  3. Wee1
  4. WEE1-IN-14

WEE1-IN-14 (Compound 14) 是一种选择性 WEE1 抑制剂 (IC50: L-RB-FEP 计算结果为 0.5 nM，ADP-Glo​​ 激酶测定中为 1.0 nM)。抑制癌细胞中的 Wee1 会破坏 G2-M 检查点，消除对细胞周期的调控，并导致有丝分裂早期失败，随后导致肿瘤细胞凋亡。因此，WEE1-IN-14 是研究癌症生物学的有用工具。

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WEE1-IN-14

WEE1-IN-14 Chemical Structure

CAS No. : 2803921-87-9

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WEE1-IN-14 相关抗体

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PKMYT1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

WEE1-IN-14 (Compound 14) is a selective WEE1 inhibitor (IC50: 0.5 nM in L-RB-FEP calculations, 1.0 nM in ADP-Glo kinase assay). Inhibition of Wee1 in cancer cells disrupts the G2-M checkpoint, removes the regulatory controls on the cell cycle, and leads to early onset of mitotic failure followed by apoptosis of tumor cells. Therefore, WEE1-IN-14 is a useful tool for studying cancer biology[1].

分子量

510.42

Formula

C25H25Cl2N7O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

WEE1-IN-14 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

WEE1-IN-142803921-87-9Wee1G2-M checkpointcell cyclewee1Inhibitorinhibitorinhibit

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目录号：
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