2. PROTAC Protein Tyrosine Kinase/RTK Neuronal Signaling
  3. PROTACs RET Trk Receptor
  4. ZW-18-116

ZW-18-116 (compound 9) 是一种针对癌蛋白 TRKA 和 RET 的双靶点 PROTAC 降解剂。ZW-18-116 通过募集 CRBN E3 连接酶诱导癌蛋白 TRKA 和 RET 的降解。ZW-18-116 在多种携带 RET 或 TRKA 融合基因的癌细胞系中表现出强效的抗增殖活性。ZW-18-116 可用于 RET 或 TRKA 衍生癌症的研究，例如甲状腺癌、肺癌和结肠癌。
(粉色: RET 配体 (HY-U00437)；蓝色: Ligands for E3 Ligase 和 Cereblon 配体 (HY-10984)；黑色: 连接子)。

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ZW-18-116

ZW-18-116 Chemical Structure

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2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

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ZW-18-116 相关抗体

Top Publications Citing Use of Products

查看 PROTACs 亚型特异性产品:

查看所有亚型
von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

查看 Trk Receptor 亚型特异性产品:

查看所有亚型
TrkA TrkB TrkC Trk

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ZW-18-116 (compound 9) is a dual-target PROTAC degrader for the oncoproteins TRKA and RET. ZW-18-116 induces the degradation of oncoproteins TRKA and RET by recruiting the CRBN E3 ligase. ZW-18-116 exhibits potent anti-proliferative activity in various cancer cell lines harboring RET or TRKA fusions. ZW-18-116 can be used for RET or TRKA-derived cancer research, such as thyroid, lung, and colon cancers[1]. (Pink: RET ligand (HY-U00437); Blue: Ligands for E3 Ligase and Cereblon ligand (HY-10984); Black: linker).

IC50 & Target[1]

TrkA

 

分子量

884.93

Formula

C46H48N10O9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ZW-18-116 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ZW-18-116PROTACsRETTrk ReceptorTropomyosin related kinase receptoroncoproteinsCRBN E3 ligaseRET or TRKA-derived cancerInhibitorinhibitorinhibit

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目录号：
HY-180550
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