| Identification | More | [Name]
3-Methyl-4-nitroaniline | [CAS]
611-05-2 | [Synonyms]
3-Amino-6-nitrotoluene
3-METHYL-4-NITROANILINE
3-METHYL-4-NITROBENZENEAMINE
3-METHYL-4-NITRO-PHENYLAMINE
4-AMINO-3-METHYL-4-NITROBENZENE
4-nitro-3-methylaniline
4-NITRO-M-TOLUIDINE
5-AMINO-2-NITROTOLUENE
3-Amino-6-nitrotoluene~4-Nitro-m-toluidine
3-METHYL-4-NITROANILINE/3-AMINO-6-NITROTOLUENE
3-METHYL-4-NITROANILINE 99%
BENZENAMINE,3-METHYL-4-NITRO | [EINECS(EC#)]
210-247-8 | [Molecular Formula]
C7H8N2O2 | [MDL Number]
MFCD00091833 | [Molecular Weight]
152.15 | [MOL File]
611-05-2.mol |
| Chemical Properties | Back Directory | [Appearance]
Brown Crystalline Solid | [Melting point ]
136-137°C | [Boiling point ]
330.0±22.0 °C(Predicted) | [density ]
1.269±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [solubility ]
Methanol | [form ]
Solid | [pka]
1.12±0.10(Predicted) | [color ]
Brown Crystalline | [BRN ]
2209112 | [CAS DataBase Reference]
611-05-2(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
T | [Risk Statements ]
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed .
R33:Danger of cumulative effects.
R51/53:Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment . | [Safety Statements ]
S28:After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) .
S36/37:Wear suitable protective clothing and gloves .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S61:Avoid release to the environment. Refer to special instructions safety data sheet . | [RIDADR ]
2660 | [HazardClass ]
6.1 | [PackingGroup ]
III | [HS Code ]
2921420090 |
| Hazard Information | Back Directory | [Chemical Properties]
Brown Crystalline Solid | [Uses]
3-Methyl-4-nitrobenzeneamine (cas# 611-05-2) is a compound useful in organic synthesis. | [Synthesis Reference(s)]
Synthetic Communications, 18, p. 2161, 1988 DOI: 10.1080/00397918808068287 | [Synthesis]
General procedure for the synthesis of 3-methyl-4-nitroaniline (20-2) from 3-methyl-4-nitrobenzamide (20-1, 40 g, 222 mmol): 20-1 was dissolved in 400 mL of methanol/water (v/v=1/1) mixed solvent and cooled to 0 °C. Subsequently, sodium hydroxide (35.6 g, 888 mmol) was added to the solution and stirred for 0.5 hours. Sodium hypochlorite solution (380 g, 556 mmol) was added slowly and dropwise at 0°C. The reaction mixture was gradually warmed up to room temperature (20°C) and stirring was continued for 18 hours. After that, the mixture was further warmed up to 35°C and stirred for 1 hour, then warmed up to 75°C and stirred for 0.5 hours. After completion of the reaction, the mixture was cooled to room temperature. The pH was adjusted to 6.0 with hydrochloric acid, at which time a brown precipitate was produced. The precipitate was collected by filtration and washed twice with 200 mL of water to give the final 20-2 (29 g, 86% yield) as a tan powder. | [References]
[1] Patent: US9138427, 2015, B2. Location in patent: Page/Page column 297 |
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