Uridin-5'-(dinatriumdihydrogentriphosphat) Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
R68/20/21/22:Gesundheitsschädlich: Möglichkeit irreversiblen Schadens durch Einatmen,Berührung mit der Haut und durch Verschlucken.
R68:Irreversibler Schaden möglich.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
White crystalline powder
Application
Uridine-5'-triphosphoric acid trisodium salt solution can be used to increase intracellular Ca2+ levels in rat primary tracheal epithelial cells. It is also used as a nucleotide substrate to analyze the activity of MutT homolog 1 (MTH1).
Allgemeine Beschreibung
Uridine 5’-triphosphate trisodium salt (UTP-Na3) is not only an essential substance for intracellular RNA synthesis and energy metabolism, but also an important extracellular signaling molecule that finely regulates a variety of key physiological functions such as inflammation, tissue repair and secretion by activating P2Y receptors.
in vitro
Uridine triphosphate (UTP) (0, 10, 100, 250, 500, and 1000 μM; 2, 4, 6, 8, 10, and 12 h) trisodium salt enhances RT4-D6P2T cells migration and wound repair. Uridine triphosphate trisodium salt induces Schwannoma cell migration through the activation of P2Y2 receptors and the increase of extracellular MMP-2 activation and expression. Uridine triphosphate (UTP) trisodium salt (Uridine-5'-triphosphoric acid trisodium salt) evokes MAPK phosphorylation in a biphasic pattern MAPK phosphorylation, with an early transient phosphorylation 5 min after treatment and a late and sustained phosphorylation that appeared at 6 h and lasted up to 24 h.
Structure and conformation
Uridine-5'-triphosphoric acid trisodium salt is composed of uridine (a nucleoside) combined with three phosphate groups and exists in the form of trisodium salt. This structure makes it well soluble in aqueous solution, and the negatively charged phosphate groups can participate in a variety of important energy transfer processes in biochemical reactions.
Uridin-5'-(dinatriumdihydrogentriphosphat) Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
