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(R)-tert-Butyl 3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate

(R)-tert-Butyl 3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate structure

CAS No.: 1022150-11-3

Chemical Name:: (R)-tert-Butyl 3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate

Synonyms: Ilutinib impurity 10;Ibrutinib Impurity 47;Ibrutinib Impurity 38;Ibrutinib iMpurity Boc;Ibrutinib Intermediates;(R)-tert-butyl 3-(4-amino-3-(4-phenoxyphenyl)-;3-[4-Amino-3-(4-phenoxy-phenyl)-pyrazolo[3,4-d]pyrimidin-1-y...;N-Boc-Ibrutinib ( tert-Butyl-1-carboxyl Piperidine analog of Ibrutinib);(R)-1-(1-Boc-3-piperidinyl)-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine;(R)-tert-Butyl 3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-ca

CBNumber:: CB02715940

Molecular Formula:: C27H30N6O3

Molecular Weight:: 486.57

MDL Number:: MFCD28167899

MOL File:: 1022150-11-3.mol

MSDS File:: SDS

Last updated:2025-07-24 18:11:54

Product description	Number	Pack Size	Price
N-Boc-Ibrutinib(tert-Butyl-1-carboxylPiperidineanalogofIbrutinib)	B656715	500mg	$700
CID59799012	6403DP	1g	$384
(R)-tert-Butyl3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate 97%	CD11364309	5g	$594
(R)-tert-Butyl3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate 97%	A224114	100mg	$14
(R)-tert-Butyl3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate 97%	A224114	250mg	$21
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(R)-tert-Butyl 3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate Properties

Boiling point	673.9±55.0 °C(Predicted)
Density	1.31±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	DMSO (Slightly), Ethyl Acetate (Slightly)
pka	4.09±0.30(Predicted)
form	Solid
color	White to Off-White
InChIKey	NTSAEGNFPKKRLX-LJQANCHMSA-N
SMILES	N1(C(OC(C)(C)C)=O)CCC[C@@H](N2C3C(C(C4=CC=C(OC5=CC=CC=C5)C=C4)=N2)=C(N)N=CN=3)C1

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338

(R)-tert-Butyl 3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate price More Price(9)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	B656715	N-Boc-Ibrutinib(tert-Butyl-1-carboxylPiperidineanalogofIbrutinib)	1022150-11-3	500mg	$700	2021-12-16	Buy
AK Scientific	6403DP	CID59799012	1022150-11-3	1g	$384	2021-12-16	Buy
Crysdot	CD11364309	(R)-tert-Butyl3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate 97%	1022150-11-3	5g	$594	2021-12-16	Buy
Ambeed	A224114	(R)-tert-Butyl3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate 97%	1022150-11-3	100mg	$14	2021-12-16	Buy
Ambeed	A224114	(R)-tert-Butyl3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate 97%	1022150-11-3	250mg	$21	2021-12-16	Buy

Product number	Packaging	Price	Buy
B656715	500mg	$700	Buy
6403DP	1g	$384	Buy
CD11364309	5g	$594	Buy
A224114	100mg	$14	Buy
A224114	250mg	$21	Buy

(R)-tert-Butyl 3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate Chemical Properties,Uses,Production

Uses

N-Boc-Ibrutinib is an impurity of Ibrutinib (I124970), which is a highly selective Bruton’s tyrosine kinase (Btk) irreversible inhibitor.

Synthesis

3-(4-phenoxyphenyl) lH-pyrazolo [3,4-d] pyrimidin-4-amine (1.14g, 3.76mmol)was dissolved DMF (30mL) in, and then the reaction solution was added (S)-tert-butyl 3-((methylsulfonyl) oxy) piperidine-1-carboxylate (4.2g, 15.04mmol), cesium carbonate(0.64mL, 8.21 mmol), 4- dimethylaminopyridine pyridine (3.67g, 11.28mmol). Was stirred at 90 ℃, the reaction was completed, distilled under reduced pressure of DMF, and extracted with dichloromethane (150mL × 3), brine (60mL), dried over anhydrous sodium sulfate; the solvent was distilled off under reduced pressure, the crude product was silica gel column Analysis of separation and purification (methylene chloride /methanol (V / V) = 40/1), to give the product (R)-tert-Butyl 3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate (1.28 g, 70 percent).

References

[1] Patent: WO2012/158795, 2012, A1. Location in patent: Page/Page column 76
[2] Patent: WO2013/191965, 2013, A1. Location in patent: Page/Page column 156
[3] Patent: WO2014/22569, 2014, A1. Location in patent: Page/Page column 50
[4] Patent: US8673925, 2014, B1. Location in patent: Page/Page column 201
[5] Patent: CN106146511, 2016, A. Location in patent: Paragraph 0150; 0151; 0152

(R)-tert-Butyl 3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate Preparation Products And Raw materials

Raw materials

(S)-1-(TERT-BUTOXYCARBONYL)PIPERIDIN-3-YL METHANESULFONATE 3-(4-Phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-4-amine Phenoxyphenyl-4-boronic acid pinacol ester (3R)-1-Boc-3-(4-aMino-3-iodo-1H-pyrazolo[3,4-d]pyriMidin-1-yl)piperidine 4-Bromophenoxybenzene

4-PHENOXYPHENYLBORONIC ACID (S)-1-Boc-3-hydroxypiperidine (S)-3-(Toluene-4-sulfonyloxy)-piperidine-1-carboxylic acid tert-butyl ester Water Sodium carbonate

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Preparation Products

(R)-tert-Butyl 3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate Suppliers

Global( 120)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Qingdao Yonghefeng Economic and Trade Co., Ltd.	+86-13375559818	cfy69@163.com	China	195	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20136	58
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29847	58
TianYuan Pharmaceutical CO.,LTD	+86-755-23284190 13684996853	sales@tianpharm.com	CHINA	304	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19552	58
Shanghai Yingrui Biopharma Co.,Ltd	21-33585366	export01@shyrchem.com	CHINA	1319	58
Neostar United (Changzhou) Industrial Co., Ltd.	+86-0519-85551759 +8613506123987	marketing1@neostarunited.com	China	8830	58
Chengdu Aslee Biopharmaceuticals, Inc.	28-85305008		CHINA	964	58
Zhengzhou Alfa Chemical Co.,Ltd	+8618530059196	sale04@alfachem.cn	China	11784	58
ANHUI WITOP BIOTECH CO., LTD	+8615255079626	eric@witopchemical.com	China	23541	58

Supplier	Advantage
Qingdao Yonghefeng Economic and Trade Co., Ltd.	58
Henan Fengda Chemical Co., Ltd	58
career henan chemical co	58
TianYuan Pharmaceutical CO.,LTD	58
BOC Sciences	58
Shanghai Yingrui Biopharma Co.,Ltd	58
Neostar United (Changzhou) Industrial Co., Ltd.	58
Chengdu Aslee Biopharmaceuticals, Inc.	58
Zhengzhou Alfa Chemical Co.,Ltd	58
ANHUI WITOP BIOTECH CO., LTD	58

View Lastest Price from (R)-tert-Butyl 3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2025-09-25	1-Piperidinecarboxylic acid, 3-[4-aMino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyriMidin-1-yl]-, 1,1-diMethylethyl ester, (3R)- 1022150-11-3	US $10.00-3.00 / kg	1kg	99%	g-kg-tons, free sample is available	Henan Fengda Chemical Co., Ltd
	2019-07-06	Ibrutinib Intermediates 1022150-11-3	US $100.00 / KG	1KG	98%	100KG	Career Henan Chemical Co

1-Piperidinecarboxylic acid, 3-[4-aMino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyriMidin-1-yl]-, 1,1-diMethylethyl ester, (3R)-
1022150-11-3
US $10.00-3.00 / kg
99%
Henan Fengda Chemical Co., Ltd

Ibrutinib Intermediates
1022150-11-3
US $100.00 / KG
98%
Career Henan Chemical Co

(R)-tert-Butyl 3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate Spectrum

(R)-tert-Butyl 3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate(1022150-11-3)¹HNMR

1022150-11-3((R)-tert-Butyl 3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate)Related Search:

Btk inhibitor 1 (R enantioMer hydrochloride) Ibrutinib Impurity 21 (S)-3-(4-phenoxyphenyl)-1-(piperidin-3-yl) (S)-3-(4-phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (R)-1-[3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]ethanone

2-Pyridinamine, 5-methyl-N,N-diphenyl- Ibrutinib Dimer Impurity (S)-Ibrutinib (R)-1-(3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)propan-1-one Ibrutinib Impurity 13

Ibrutinib Impurity 4 3-(4-Phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-4-amine Ibrutinib Impurity 6 Ibrutinib Impurity 12 Ibrutinib Impurity 3

(S)-1-Boc-3-hydroxypiperidine Ibrutinib Impurity 14 (R)-1-[3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]-3-chloropropan-1-one

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1-Piperidinecarboxylic acid, 3-[4-aMino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyriMidin-1-yl]-, 1,1-diMethylethyl ester, (3R)- (R)-tert-Butyl 3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate (R)-tert-Butyl 3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate (N-1) 3-[4-Amino-3-(4-phenoxy-phenyl)-pyrazolo[3,4-d]pyrimidin-1-yl]-piperidine-1-carboxylic acid tert-butyl ester (R)-1-(1-Boc-3-piperidinyl)-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (R)-3-[4-Amino-3-(4-phenoxy-phenyl)- pyrazolo[3,4-d]pyrimidin-1-yl]- piperidine-1-carboxylic acid tert-butyl ester (R)-tert-butyl 3-(4-amino-3-(4-phenoxyphenyl)- tert-butyl (3R)-3-[4-amino-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate Ibrutinib impurity 5/(R)-tert-butyl 3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-piperidine-1-carboxylate (R)-3-[4-Amino-3-(4-phenoxy-phenyl)-pyrazolo[3,4-d]pyrimidin-1-yl]-piperidine-1-carboxylic acid Ibrutinib Intermediates (R)-tert-Butyl 3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-ca 3-[4-Amino-3-(4-phenoxy-phenyl)-pyrazolo[3,4-d]pyrimidin-1-yl]-piperidine-1-carboxylic acid tert-but N-Boc-Ibrutinib ( tert-Butyl-1-carboxyl Piperidine analog of Ibrutinib) Ibrutinib iMpurity Boc 3-[4-Amino-3-(4-phenoxy-phenyl)-pyrazolo[3,4-d]pyrimidin-1-y... tert-butyl (R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate Ibrutinib Impurity 47 1-Piperidinecarboxylicacid,3-[4-aMino-3-(4-phenoxyphenyl)-Chemicalbook1H-pyrazolo[3,4-d]pyriMidin-1-yl]-,1,1-diMethylethylester,(3R)- Ibrutinib Impurity 38 Ilutinib impurity 10 tert -butyl (R)-3-[4-Amino-3-(4-phenoxy-phenyl)-pyrazolo[3,4-d]pyrimidin-1-yl]-piperidine-1-carboxylate (R)-tert-Butyl 3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxyl 1022150-11-3