6-NITROQUINAZOLIN-4(3H)-ONE
- CAS No.
- 6943-17-5
- Chemical Name:
- 6-NITROQUINAZOLIN-4(3H)-ONE
- Synonyms
- NSC 51669;Afatinib Impurity 102;6-NITRO-4-QUINAZOLONE;6-NITROQUINAZOLIN-4-OL;6-Nitro-4-quinazolinol;6-NITROQUIZOLIN-4(3H)-ONE;6-NITRO-4(3H)-QUINAZOLINONE;6-NITROQUINAZOLIN-4(3H)-ONE;6-Nitro-3H-quinazolin-4-one;6-NITRO-4(1H)-QUINAZOLINONE
- CBNumber:
- CB1676877
- Molecular Formula:
- C8H5N3O3
- Molecular Weight:
- 191.14
- MDL Number:
- MFCD08460966
- MOL File:
- 6943-17-5.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 6-Nitro-4-quinazolone | N596450 | 500mg | $525 |
| 6-Nitro-4-quinazolone | N596450 | 1g | $950 |
| 6-NITROQUINAZOLIN-4-OL 95.00% | CHM0076033 | 1G | $1686.3 |
| 6-Nitroquinazolin-4(3H)-one | V7338 | 100g | $1882 |
| 6-NITROQUINAZOLIN-4-OL 95.00% | CHM0076033 | 100MG | $716.1 |
| More product size | |||
| Melting point | 286-287 °C |
|---|---|
| Boiling point | 407.0±47.0 °C(Predicted) |
| Density | 1?+-.0.1 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly, Heated) |
| form | Solid |
| pka | -1.01±0.20(Predicted) |
| color | Yellow |
| InChI | InChI=1S/C8H5N3O3/c12-8-6-3-5(11(13)14)1-2-7(6)9-4-10-8/h1-4H,(H,9,10,12) |
| InChIKey | MOBNCKURXDGQCB-UHFFFAOYSA-N |
| SMILES | N1C2=C(C=C([N+]([O-])=O)C=C2)C(=O)NC=1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H335-H319-H315-H302 |
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P-P264-P270-P301+P312-P330-P501 |
| HazardClass | IRRITANT |
6-NITROQUINAZOLIN-4(3H)-ONE price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | N596450 | 6-Nitro-4-quinazolone | 6943-17-5 | 500mg | $525 | 2021-12-16 | Buy |
| TRC | N596450 | 6-Nitro-4-quinazolone | 6943-17-5 | 1g | $950 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0076033 | 6-NITROQUINAZOLIN-4-OL 95.00% | 6943-17-5 | 1G | $1686.3 | 2021-12-16 | Buy |
| AK Scientific | V7338 | 6-Nitroquinazolin-4(3H)-one | 6943-17-5 | 100g | $1882 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0076033 | 6-NITROQUINAZOLIN-4-OL 95.00% | 6943-17-5 | 100MG | $716.1 | 2021-12-16 | Buy |
6-NITROQUINAZOLIN-4(3H)-ONE Chemical Properties,Uses,Production
Chemical Properties
Yellow Solid
Uses
Intermediate in the preparation of anticancer agents and enzyme inhibitors.
Synthesis
77287-34-4
616-79-5
6943-17-5
1. Preparation of 6-nitro-3H-quinazolin-4-one: 150 g of 2-amino-5-nitrobenzoic acid was added to 200 ml of formamide and stirred until completely dissolved. The reaction mixture was heated to 170°C and maintained at this temperature for 4 hours. After completion of the reaction, the mixture was cooled to 100°C. 500 ml of ice water was slowly added and stirring was continued for 1 hour. Subsequently, the mixture was filtered under reduced pressure and the solid product was collected. The solid was washed with plenty of water to remove residual reactants and by-products. Finally, the resulting solid was dried at 40 °C for 15 h to afford 4-hydroxy-6-nitroquinazoline (140 g, 90% yield). The structure of the product was confirmed by 1H-NMR (DMSO-d6, 300 MHz): δ8.77 (d, J = 2.7 Hz, 1H), 8.55 (dd, J = 6.9 Hz, 1H), 8.36 (s, 1H), 7.84 (d, J = 9 Hz, 1H).
References
[1] Patent: WO2006/71017, 2006, A1. Location in patent: Page/Page column 34
[2] Tetrahedron Letters, 2002, vol. 43, # 21, p. 3911 - 3913
[3] Tetrahedron Letters, 2003, vol. 44, # 24, p. 4455 - 4458
[4] Patent: US2005/187231, 2005, A1. Location in patent: Page/Page column 14
[5] Tetrahedron, 2013, vol. 69, # 15, p. 3182 - 3191
6-NITROQUINAZOLIN-4(3H)-ONE Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29735 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29849 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14332 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49975 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | sale04@alfachem.cn | China | 11855 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
View Lastest Price from 6-NITROQUINAZOLIN-4(3H)-ONE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-10 | 6-NITROQUINAZOLIN-4(3H)-ONE
6943-17-5
|
US $1.00 / KG | 1KG | 98% | 150KG | Career Henan Chemical Co |
-
- 6-NITROQUINAZOLIN-4(3H)-ONE
6943-17-5
- US $1.00 / KG
- 98%
- Career Henan Chemical Co
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