Purmorphamine
- CAS No.
- 483367-10-8
- Chemical Name:
- Purmorphamine
- Synonyms
- CS-1816;Purmorphamin;PURMORPHAMINE;Purmorphamine, >=98%;Purmorphamine USP/EP/BP;Shh Signaling Antagonist VI;Purmorphamine, 10 mM in DMSO;Purmorphamine, Smoothened receptor agonist;inhibit,Purmorphamine,Autophagy,Smo,Smoothened,Inhibitor;2-(1-NAPHTHOXY)-6-(4-MORPHOLINOANILINO)-9-CYCLOHEXYLPURINE
- CBNumber:
- CB2841106
- Molecular Formula:
- C31H32N6O2
- Molecular Weight:
- 520.62
- MDL Number:
- MFCD09037557
- MOL File:
- 483367-10-8.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Purmorphamine ≥98% (HPLC) | SML0868 | 5mg | $154 |
| Purmorphamine ≥98% (HPLC) | SML0868 | 25mg | $615 |
| Purmorphamine InSolution, ≥98%, 50 mM in DMSO, induces osteoblast differentiation in C3H10T1/2 multipotent mesenchymal progenitor cells | 540223 | 5mg | $246 |
| Purmorphamine | P3217 | 20MG | $87 |
| Purmorphamine ≥98% | 10009634 | 1mg | $29 |
| More product size | |||
| Melting point | 210-212°C |
|---|---|
| Boiling point | 790.3±70.0 °C(Predicted) |
| Density | 1.35±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | DMSO: soluble5mg/mL, clear (warmed) |
| pka | 5.44±0.40(Predicted) |
| form | powder |
| color | white to beige |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| InChIKey | FYBHCRQFSFYWPY-UHFFFAOYSA-N |
| SMILES | N7(CCOCC7)c1ccc(cc1)Nc2nc(nc5[n](cnc52)C6CCCCC6)Oc3c4c(ccc3)cccc4 |
| FDA UNII | PB12M2F8KY |
| UNSPSC Code | 51111800 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Warning |
| Hazard statements | H341 |
| Precautionary statements | P201-P202-P280-P308+P313-P405-P501 |
| WGK Germany | 3 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Muta. 2 |
Purmorphamine price More Price(41)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0868 | Purmorphamine ≥98% (HPLC) | 483367-10-8 | 5mg | $154 | 2025-07-31 | Buy |
| Sigma-Aldrich | SML0868 | Purmorphamine ≥98% (HPLC) | 483367-10-8 | 25mg | $615 | 2025-07-31 | Buy |
| Sigma-Aldrich | 540223 | Purmorphamine InSolution, ≥98%, 50 mM in DMSO, induces osteoblast differentiation in C3H10T1/2 multipotent mesenchymal progenitor cells | 5mg | $246 | 2025-07-31 | Buy | |
| TCI Chemical | P3217 | Purmorphamine | 483367-10-8 | 20MG | $87 | 2025-07-31 | Buy |
| Cayman Chemical | 10009634 | Purmorphamine ≥98% | 483367-10-8 | 1mg | $29 | 2024-03-01 | Buy |
Purmorphamine Chemical Properties,Uses,Production
Description
Small molecules that promote osteoblast differentiation might be useful as therapeutic agents for bone diseases such as osteoporosis. Purmorphamine is a 2,6,9-
Chemical Properties
Light Tan Solid
Uses
An activator of the hedgehog (Hh) signaling pathway.
Uses
Purmorphamine has been used to study the consequences of upregulation of Hedgehog signalling pathway in Tupfel long fin strain Zebrafish.
Uses
Activates the Hedgehog pathway by targeting Smoothened
Definition
ChEBI: A member of the class of purines that is purine substituted at C-2 by a 1-naphthyloxy group, at C-4 by a 4-morpholinophenylamino group, and at N-9 by a cyclohexyl group.
Biochem/physiol Actions
Purmorphamine activates the Hedgehog (Hh) signaling pathway, directly binding to the Smoothened (Smo) receptor. In various studies, purmorphamine has been shown to induce osteoblast differentiation, generate cardiomyocytes from human embryonic stem cells, increase the neuronal differentiation of a human striatal neural stem cell line, and to differentiate human umbilical cord mesenchymal stem cells (hUCMSCs) into motoneurons.
in vitro
purmorphamine activated the hedgehog pathway by directly bound and activated smoothened with the ic50value of ~ 1.5 μm in competing with cyclopamine, a smo antagonist [1]. in multi-potent c3h10t1/2 cells, purmorphamine was a potent inducer of osteogenesis. in c3h10t1/2 cells, the ec50 values assessed based on alp expression for purmorphamine was 1 μm. purmorphamine (1 μm) in combination with bmp-4 (100 ng/ml) increased alp activity more than 90-fold in 3t3-l1 cells [3].administration of purmorphamine at 3 and 5 μm up-regulated the level of osteocalcin on day 14 (p ≤ 0.05)[4].
in vivo
in rats transplanted with stem cell-based constructs subcutaneously, treatment with purmorphamine tended to up-regulate alp transcripts when compared with those injected by either dexamethasone or injection water (p ≤ 0.05) [4].
storage
-20°C
References
[1] XU WU. A Small Molecule with Osteogenesis-Inducing Activity in Multipotent Mesenchymal Progenitor Cells[J]. Journal of the American Chemical Society, 2002, 124 49: 14520-14521. DOI:10.1021/ja0283908
[2] XU WU. Purmorphamine induces osteogenesis by activation of the hedgehog signaling pathway.[J]. Chemistry & biology, 2004, 11 9: 1229-1238. DOI:10.1016/j.chembiol.2004.06.010
[3] SURAJIT SINHA James K C. Purmorphamine activates the Hedgehog pathway by targeting Smoothened[J]. Nature chemical biology, 2005, 2 1: 29-30. DOI:10.1038/nchembio753
[4] PHIL JUN KANG . Reprogramming of mouse somatic cells into pluripotent stem-like cells using a combination of small molecules[J]. Biomaterials, 2014, 35 26: Pages 7336-7345. DOI:10.1016/j.biomaterials.2014.05.015
[5] LEI ZHANG. Small Molecules Efficiently Reprogram Human Astroglial Cells into Functional Neurons.[J]. Cell stem cell, 2015, 17 6: 735-747. DOI:10.1016/j.stem.2015.09.012
Purmorphamine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29833 | 58 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 965 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| TopScience Biochemical | 00852-68527855 | info@itopbiochem.com | China Hong Kong | 902 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5742 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32470 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 19581 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471; | sales@sarms4muscle.com | China | 10473 | 58 |
| Henan Alfa Chemical Co., Ltd | +8615838112936 | alfa10@alfachem.cn | China | 12920 | 58 |
View Lastest Price from Purmorphamine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-09-04 | Purmorphamine
483367-10-8
|
US $5.00 / KG | 1KG | 99% | 1ton | Career Henan Chemical Co |
-
- Purmorphamine
483367-10-8
- US $5.00 / KG
- 99%
- Career Henan Chemical Co
