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(D-Ala2)-Leu-Enkephalin

(D-Ala2)-Leu-Enkephalin structure

CAS No.: 64963-01-5

Chemical Name:: (D-Ala2)-Leu-Enkephalin

Synonyms: (D-ALA2)-LEU-ENKEPHALIN;TYR-D-ALA-GLY-PHE-LEU;D-ALA2-LEU5-ENKEPHALIN;(D-Ala)-Leu-Enkephalin;Pentapeptide-18 Peptide;Tyr-D-Ala-Gly-Phe-Leu-OH;Pentapeptide-3/Leuphasyl;H-TYR-D-ALA-GLY-PHE-LEU-OH;Leuphasyl / Pentapeptide-3;[D-ALA2]-LEUCINE ENKEPHALIN

CBNumber:: CB3667734

Molecular Formula:: C29H39N5O7

Molecular Weight:: 569.65

MDL Number:: MFCD00076409

MOL File:: 64963-01-5.mol

Last updated:2026-01-23 16:19:27

Product description	Number	Pack Size	Price
[D-Ala2]-Leucine enkephalin ≥97% (HPLC)	E5008	5mg	$107
[D-Ala2]-Leucine enkephalin 99.77%	CS-5905	10mg	$108
(D-Ala2)-Leu-Enkephalin H-Tyr-D-Ala-Gly-Phe-Leu-OH	FA108766	25mg	$181
[D-Ala2]-Leucine enkephalin 99.77%	CS-5905	50mg	$420
[D-Ala2]-Leucine enkephalin 97%	AS112962	25mg	$424
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(D-Ala2)-Leu-Enkephalin Properties

Melting point	160-163.5 °C
Boiling point	991.9±65.0 °C(Predicted)
Density	1.257±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility	DMF (Slightly), DMSO (Slightly)
pka	3.40±0.10(Predicted)
form	Solid
color	White to Off-White
Sequence	Tyr-{d-Ala}-Gly-Phe-Leu
InChIKey	ZHUJMSMQIPIPTF-JMBSJVKXSA-N
SMILES	C(O)(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@H](CC1=CC=C(O)C=C1)N
FDA UNII	PO4D55T1IG
UNSPSC Code	12352209
NACRES	NA.26

SAFETY

Risk and Safety Statements

WGK Germany	3
Storage Class	11 - Combustible Solids

(D-Ala2)-Leu-Enkephalin price More Price(12)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	E5008	[D-Ala2]-Leucine enkephalin ≥97% (HPLC)	64963-01-5	5mg	$107	2025-07-31	Buy
ChemScene	CS-5905	[D-Ala2]-Leucine enkephalin 99.77%	64963-01-5	10mg	$108	2021-12-16	Buy
Biosynth Carbosynth	FA108766	(D-Ala2)-Leu-Enkephalin H-Tyr-D-Ala-Gly-Phe-Leu-OH	64963-01-5	25mg	$181	2021-12-16	Buy
ChemScene	CS-5905	[D-Ala2]-Leucine enkephalin 99.77%	64963-01-5	50mg	$420	2021-12-16	Buy
Activate Scientific	AS112962	[D-Ala2]-Leucine enkephalin 97%	64963-01-5	25mg	$424	2021-12-16	Buy

Product number	Packaging	Price	Buy
E5008	5mg	$107	Buy
CS-5905	10mg	$108	Buy
FA108766	25mg	$181	Buy
CS-5905	50mg	$420	Buy
AS112962	25mg	$424	Buy

(D-Ala2)-Leu-Enkephalin Chemical Properties,Uses,Production

Uses

[D-Ala2]leucine-enkephalin, a delta opioid agonist, is a degradation resistant long-acting Leu-enkephalin.

Definition

The leucine-enkephalin (Tyr-Gly-Gly-Phe-Leu, Leu-enk) is a natural endogenous ligand for opiate receptors. Leu-enk is rapidly metabolized in vivo and in vitro[1]. (D-Ala2)-Leu-Enkephalin, a delta opioid agonist, is a degradation resistant long-acting Leu-enkephalin.

benefits

(D-Ala2)-Leu-Enkephalin is widely distributed in the human body and has essential physiological functions. It has a unique effect on brain cells and can activate sleeping brain cells and have a good recovery effect on the sequelae caused by brain damage. It plays an important role in immune function, including increasing the activity of the immune system, T lymphocytes, NK cells, macrophages, antiviral, and the release of gamma interferon. It can participate in immune regulation by promoting the secretion of endocrine cells by activated immune cells, thereby affecting DNA's gene regulation and expression functions.

IC 50

δ Opioid Receptor/DOR

References

[1] H. Hasegawa, S. Baba, Y. Shinohara. “Synthesis of [D-Ala2]Leu-enkephalin and [D-Ala2, D-Leu5]Leu-enkephalin with high specific tritiated activity in the leucine residue.” Journal of The Chemical Society-perkin Transactions 1 12 1 (1990): 2641–2644.

(D-Ala2)-Leu-Enkephalin Preparation Products And Raw materials

Raw materials

Preparation Products

(D-Ala2)-Leu-Enkephalin Suppliers

Global( 236)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Cellmano Biotech Limited	0551-65326643 18156095617	info@cellmano.com	China	995	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8753	58
Shanghai Yunao International Trade Co., Ltd	+8617621705551	asdf@shanghaihg.cn	China	264	58
Wuhan Cell Pharmaceutical Co., Ltd	+86-13129979210	sales@cellwh.com	China	376	58
Wuhan Haorong Biotechnology Co.,ltd	+8618565342920	sales@chembj.net	China	304	58
Nantong Guangyuan Chemicl Co,Ltd	+undefined17712220823	admin@guyunchem.com	China	615	58
Chongqing Zhihe Biopharmaceutical Co., Ltd.	+86-18580541567 +86-17782035140	sales@zhswyy.com	China	240	58
Shanghai Affida new material science and technology center	+undefined15081010295	admin@oudaxin.com	China	114	58
Shaanxi TNJONE Pharmaceutical Co., Ltd	+8618092446649	sarah@tnjone.com	China	1143	58
Shanghai Getian Industrial Co., LTD	+86-15373193816	mike@ge-tian.com	China	269	58

Supplier	Advantage
Cellmano Biotech Limited	58
Hebei Chuanghai Biotechnology Co., Ltd	58
Shanghai Yunao International Trade Co., Ltd	58
Wuhan Cell Pharmaceutical Co., Ltd	58
Wuhan Haorong Biotechnology Co.,ltd	58
Nantong Guangyuan Chemicl Co,Ltd	58
Chongqing Zhihe Biopharmaceutical Co., Ltd.	58
Shanghai Affida new material science and technology center	58
Shaanxi TNJONE Pharmaceutical Co., Ltd	58
Shanghai Getian Industrial Co., LTD	58

View Lastest Price from (D-Ala2)-Leu-Enkephalin manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-02-07	Pentapeptide-18 64963-01-5	US $0.00-0.00 / g	1g	99%	1kg	Xi an Biohorlden Industry Trade Co Ltd
2026-02-01	(D-Ala2)-Leu-Enkephalin 64963-01-5	US $0.00-0.00 / kg	0.10000000149011612kg	99%	2000kgs	Chongqing Zhihe Biopharmaceutical Co., Ltd.
2026-01-30	TYR-D-ALA-GLY-PHE-LEU 64963-01-5	US $10.00 / KG	1KG	99%	10 mt	Hebei Chuanghai Biotechnology Co., Ltd

Pentapeptide-18
64963-01-5
US $0.00-0.00 / g
99%
Xi an Biohorlden Industry Trade Co Ltd

(D-Ala2)-Leu-Enkephalin
64963-01-5
US $0.00-0.00 / kg
99%
Chongqing Zhihe Biopharmaceutical Co., Ltd.

TYR-D-ALA-GLY-PHE-LEU
64963-01-5
US $10.00 / KG
99%
Hebei Chuanghai Biotechnology Co., Ltd

(D-Ala2)-Leu-Enkephalin Spectrum

(D-Ala2)-Leu-Enkephalin(64963-01-5)¹HNMR

64963-01-5((D-Ala2)-Leu-Enkephalin)Related Search:

Palmitoyl Tetrapeptide-3 Palmitoyl Pentapeptide Palmitoyl Tripeptide-5 Acetyl Tetrapeptide-5 NONAPEPTIDE-1

Acetyl octapeptide-1 PALMITOYL TRIPEPTIDE-1 Lipopeptide Acetate Palmitoyl Pentapeptide-3 Matrixyl，PALMITOYL PENTAPEPTIDE-3

TYR-D-ALA-GLY-PHE-MET ACOH H2O Hexapeptide 9 HEXAPEPTIDE-3 Aprotinin Glycyl-L-prolyl-L-arginyl-L-prolyl-L-alaninamide

Pentapeptide-25 (D-Ala2)-Leu-Enkephalin H-TYR-D-ALA-GLY-PHE-LEU-ARG-ARG-ILE-ARG-OH

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H-TYR-D-ALA-GLY-PHE-LEU-OH (D-ALA2)-LEU-ENKEPHALIN D-ALA2-LEU5-ENKEPHALIN [D-ALA2]-LEUCINE ENKEPHALIN TYR-D-ALA-GLY-PHE-LEU N-[N-[N-(N-L-tyrosyl-D-alanyl)glycyl]-L-phenylalanyl]-L-leucine (D-alanine2)leucine enkephalin L-Tyr-D-Ala-Gly-L-Phe-L-Leu-OH (D-Ala2)-Leu-Enkephalin H-Tyr-D-Ala-Gly-Phe-Leu-OH (D-Ala)-Leu-Enkephalin [D-ALA2]LEUCINE-ENKEPHALIN, >99% [D-Ala2]leucine-enkephalin,Tyr-D-Ala-Gly-Phe-Leu, >99% Tyr-D-Ala-Gly-Phe-Leu-OH 2-[[2-[[2-[2-[[2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoylamino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoic acid 2-[[2-[[2-[2-[[2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoylamino]acetyl]amino]-3-phenyl-propanoyl]amino]-4-methyl-valeric acid 2-[[2-[2-[2-[[2-azanyl-3-(4-hydroxyphenyl)propanoyl]amino]propanoylamino]ethanoylamino]-3-phenyl-propanoyl]amino]-4-methyl-pentanoic acid [D-Ala2]-Leucine enkephalin,Tyr-D-Ala-Gly-Phe-Leu Pentapeptide-3/Leuphasyl L-Tyrosyl-D-alanylglycyl-L-phenylalanyl-L-leucine Tyrosyl-D-alanylglycylphenylalanylleucine Leuphasyl / Pentapeptide-3 Leuphasyl / Pentapeptide-18 Pentapeptide-18/Leuphasyl with reduce facial muscle L-Leucine, L-tyrosyl-D-alanylglycyl-L-phenylalanyl- 2-[[2-[[2-[2-[[2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoylamino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoicaci TYR-D-ALA-GLY-PHE-LEU USP/EP/BP Lab Supply High Purity Pentapeptide-18 Powder CAS 64963-01-5 with Best Price Pentapeptide-18 Peptide 64963-01-5 C29H39N5O7 Enkephalins Opioid Peptides Peptides Biochemicals and Reagents Amino Acids and Peptides BioChemical