ChemicalBook >> CAS DataBase List >>4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methylbenzoic acid

4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methylbenzoic acid

4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methylbenzoic acid structure

CAS No.: 864725-62-2

Chemical Name:: 4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methylbenzoic acid

Synonyms: 4-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2-methylbenzoic acid;Fluralaner-024;Fluralaner Impurity 3;Fluralaner Impurity 2;Fluralaner Impurity 6;Flurellana Impurity 4;Fluralaner N-1 intermediate;Intermediate of FluralanerⅢ;Chemical Formula: C18H12Cl2F3NO3 Molecular Weight: 418.19;4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-1,2-oxazol-3-yl]-2-methylbenzoic acid

CBNumber:: CB43364743

Molecular Formula:: C18H12Cl2F3NO3

Molecular Weight:: 418.19

MDL Number:

MOL File:: 864725-62-2.mol

MSDS File:: SDS

Last updated:2025-09-22 14:50:28

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4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methylbenzoic acid Properties

Boiling point	511.3±60.0 °C(Predicted)
Density	1.49±0.1 g/cm3(Predicted)
storage temp.	2-8°C Refrigerator
pka	3.61±0.25(Predicted)
Appearance	White to off-white Solid
InChI	InChI=1S/C18H12Cl2F3NO3/c1-9-4-10(2-3-14(9)16(25)26)15-8-17(27-24-15,18(21,22)23)11-5-12(19)7-13(20)6-11/h2-7H,8H2,1H3,(H,25,26)
InChIKey	KBWVSPGZOPXKRR-UHFFFAOYSA-N
SMILES	C(O)(=O)C1=CC=C(C2CC(C3=CC(Cl)=CC(Cl)=C3)(C(F)(F)F)ON=2)C=C1C

4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methylbenzoic acid Chemical Properties,Uses,Production

Uses

4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methylbenzoic acid is an organic intermediate compound used in the synthesis of Fluralaner.

Synthesis

4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methylbenzoic acid is prepared by the reaction of 2-methyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzoic acid and 3-bromo-5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole. The steps are as follows:
In a 100 mL three-necked flask, under nitrogen protection, add 3-bromo-5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole (700 mg, 1.93 mmoL), 2-methyl-4-(4,4,5,5-tetramethyl-1,3-dioxaborolan-2-yl)benzoic acid (560 mg, 2.14 mmoL), potassium acetate (379 mg, 3.86mmol), 1,4-dioxane (15mL), water (1.5mL) and Pd(dppf)Cl2 (141mg, 0.19mmol), incubate the reaction at 85±5 for 8h, stop heating to room temperature, then Water (50 mL) was added to quench and then extracted with dichloromethane (45 mL×2), the organic phases were combined, the organic phase was washed once with saturated brine (50 mL), and then the organic phase was washed with anhydrous sodium sulfate (10.0 g). ) was dried for 2 h, the organic phase was concentrated to dryness under reduced pressure, and the concentrated residue was purified by silica gel column chromatography (developing solvent: n-heptane/ethyl acetate=10:1-3:1) to obtain 4-(5-(3 ,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2-methylbenzoic acid (694 mg, 86%) as a pale yellow solid.
4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methylbenzoic acid synthesis

4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methylbenzoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methylbenzoic acid Suppliers

Global( 117)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Xinsheng New Material Technology Co., LTD.	+86-16632316109	xinshengkeji@xsmaterial.com	China	1085	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21614	55
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
Shanghai UCHEM Inc.	+862156762820 +86-13564624040	sales@myuchem.com	China	8460	58
Hainan Mike Biomedical Technology Co., Ltd	+86-15120707353 +86-18876637353	tunanmedicine@hotemail.com	China	43	58
ChemExpress	+86-19370970350 +86-021-58950125	info@chemexpress.com	China	787	58
Henan Alfa Chemical Co., Ltd	+8615838112936	alfa10@alfachem.cn	China	12921	58
Shanghai Joiny Pharmaceutical Co.,LTD	+86-13681955282 +86-13681955282;	gyd@joiny-pharma.com	China	383	58
Nanjing Doge Biomedical Technology Co., Ltd	+86-25-58227606 +86-15305155328	sales@dogechemical.com	China	4128	58
Changsha Junyu Chemexpress.co., Ltd	+86-13723890100	info@csjyyy.cn	China	134	58

Supplier	Advantage
Hebei Xinsheng New Material Technology Co., LTD.	58
Henan Tianfu Chemical Co.,Ltd.	55
Accela ChemBio Inc.	58
Shanghai UCHEM Inc.	58
Hainan Mike Biomedical Technology Co., Ltd	58
ChemExpress	58
Henan Alfa Chemical Co., Ltd	58
Shanghai Joiny Pharmaceutical Co.,LTD	58
Nanjing Doge Biomedical Technology Co., Ltd	58
Changsha Junyu Chemexpress.co., Ltd	58

View Lastest Price from 4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methylbenzoic acid manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-12-01	4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methylbenzoic acid 864725-62-2	US $0.00 / kg	1kg	98%	10000KGS	Shaanxi Dideu New Materials Co. Ltd
2025-11-19	4-(5-(3,5-Dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2-methylbenzoic acid 864725-62-2	US $0.00 / kg	1kg	99%	1000kg	Shanghai Joiny Pharmaceutical Co.,LTD
2025-04-04	4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methylbenzoic acid 864725-62-2	US $0.00-0.00 / kg	1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.

4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methylbenzoic acid
864725-62-2
US $0.00 / kg
98%
Shaanxi Dideu New Materials Co. Ltd

4-(5-(3,5-Dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2-methylbenzoic acid
864725-62-2
US $0.00 / kg
99%
Shanghai Joiny Pharmaceutical Co.,LTD

4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methylbenzoic acid
864725-62-2
US $0.00-0.00 / kg
98%
Henan Aochuang Chemical Co.,Ltd.

864725-62-2(4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methylbenzoic acid)Related Search:

1,3-dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene 2-AMino-N-(2,2,2-trifluoroethyl)acetaMide hydrochloride Fluralaner Impurity 5 3-(4-bromo-3-methylphenyl)-5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole Fluralaner Impurity 4

Fluralaner 3',5'-DICHLORO-2,2,2-TRIFLUOROACETOPHENONE

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4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methylbenzoic acid 4-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2-methylbenzoic acid Fluralaner Impurity 2 Fluralaner Impurity 3 Fluralaner-024 Fluralaner Impurity 6 Fluralaner N-1 intermediate Benzoic acid, 4-[5-(3,5-dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-2-methyl- 4-[5-(3,5-Dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-3-isoxazolyl]-2-methylbenzoic Acid Chemical Formula: C18H12Cl2F3NO3 Molecular Weight: 418.19 Intermediate of FluralanerⅢ Flurellana Impurity 4 4-[5-(3,5-Dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-2-methylbenzoic acid 4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazoloxazol-3-yl]-2-methylbenzoic acid 4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-1,2-oxazol-3-yl]-2-methylbenzoic acid 864725-62-2 API