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ChemicalBook >> CAS DataBase List >>3',5'-DICHLORO-2,2,2-TRIFLUOROACETOPHENONE

3',5'-DICHLORO-2,2,2-TRIFLUOROACETOPHENONE

3',5'-DICHLORO-2,2,2-TRIFLUOROACETOPHENONE Structure
3',5'-DICHLORO-2,2,2-TRIFLUOROACETOPHENONE structure
CAS No.
130336-16-2
Chemical Name:
3',5'-DICHLORO-2,2,2-TRIFLUOROACETOPHENONE
Synonyms
1-(3,5-dichlorophenyl)-2,2,2-trifluoroethan-1-one;1-(3,5-DICHLORO-PHENYL)-2,2,2-TRIFLUORO-ETHANONE;uoroethanone;1-(3,5-DichL;5-DICHLORO-2;)-2,2,2-trifL;Fluralaner-002;Acetophenone673;Fluralaner Impurity 28;2-TRIFLUOROACETOPHENONE
CBNumber:
CB0206550
Molecular Formula:
C8H3Cl2F3O
Molecular Weight:
243.01
MDL Number:
MFCD01319996
MOL File:
130336-16-2.mol
Last updated:2025-09-22 14:50:28
Product description Number Pack Size Price
3',5'-Dichloro-2,2,2-trifluoroacetophenone >96.0%(GC) D5113 1g $43
3',5'-Dichloro-2,2,2-trifluoroacetophenone >96.0%(GC) D5113 5g $169
3'',5''-Dichloro-2,2,2-trifluoroacetophenone D436405 25g $730
3',5'-DICHLORO-2,2,2-TRIFLUORO ACETOPHENONE 95.00% HCH0012118 1G $818.61
3',5'-Dichloro-2,2,2-trifluoroacetophenone 97% 6518-2 5g $1059
More product size
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3',5'-DICHLORO-2,2,2-TRIFLUOROACETOPHENONE Properties

Boiling point 265℃
Density 1.506
refractive index 1.4980 to 1.5020
Flash point 114℃
storage temp. Sealed in dry,Room Temperature
solubility Acetonitrile (Slightly), Chloroform (Slightly), Methanol (Slightly)
form Oil
color Colourless
InChI InChI=1S/C8H3Cl2F3O/c9-5-1-4(2-6(10)3-5)7(14)8(11,12)13/h1-3H
InChIKey DZDSQRPDUCSOQV-UHFFFAOYSA-N
SMILES C(=O)(C1=CC(Cl)=CC(Cl)=C1)C(F)(F)F
CAS DataBase Reference 130336-16-2

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
Risk Statements  36/37/38
Safety Statements  26-36/37/39
HS Code  2914790090
NFPA 704
1
2 0

3',5'-DICHLORO-2,2,2-TRIFLUOROACETOPHENONE price More Price(33)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical D5113 3',5'-Dichloro-2,2,2-trifluoroacetophenone >96.0%(GC) 130336-16-2 1g $43 2025-07-31 Buy
TCI Chemical D5113 3',5'-Dichloro-2,2,2-trifluoroacetophenone >96.0%(GC) 130336-16-2 5g $169 2025-07-31 Buy
TRC D436405 3'',5''-Dichloro-2,2,2-trifluoroacetophenone 130336-16-2 25g $730 2021-12-16 Buy
American Custom Chemicals Corporation HCH0012118 3',5'-DICHLORO-2,2,2-TRIFLUORO ACETOPHENONE 95.00% 130336-16-2 1G $818.61 2021-12-16 Buy
Rieke Metals 6518-2 3',5'-Dichloro-2,2,2-trifluoroacetophenone 97% 130336-16-2 5g $1059 2021-12-16 Buy
Product number Packaging Price Buy
D5113 1g $43 Buy
D5113 5g $169 Buy
D436405 25g $730 Buy
HCH0012118 1G $818.61 Buy
6518-2 5g $1059 Buy

3',5'-DICHLORO-2,2,2-TRIFLUOROACETOPHENONE Chemical Properties,Uses,Production

Uses

3'',5''-Dichloro-2,2,2-trifluoroacetophenone is a reagent used for enantioselective preparation of benzazephinoindoles bearing trifluoromethylated quaternary stereocenters catalyzed by chiral spirocyclic phosphoric acids

Synthesis

1-Bromo-3,5-dichlorobenzene

19752-55-7

Trifluoroacetic anhydride

407-25-0

3',5'-DICHLORO-2,2,2-TRIFLUOROACETOPHENONE

130336-16-2

Under nitrogen protection, tert-butyllithium (1.3 M in pentane, 17.8 mL, 23.2 mmol) was slowly added dropwise to a solution of 3,5-dichloro-1-bromobenzene (5.0 g, 22.1 mmol) in tetrahydrofuran (50 mL) over a period of 30 min, followed by continuing the reaction for 2 h at -78 °C. Upon completion of the reaction, trifluoroacetic anhydride (2.56 g, 12.2 mmol) was slowly added dropwise to the reaction mixture and stirring was continued for 2 hours at -78 °C. The cooling bath was removed and the reaction mixture was allowed to warm slowly to room temperature and stirring was continued at room temperature for 2.5 hours. When the reaction was terminated, saturated ammonium chloride solution (50 mL) was added. The reaction mixture was extracted with ether (3 x 50 mL) and the organic phases were combined and washed with saturated brine (20 mL x 2). The organic phase was separated, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure, and purified by distillation under reduced pressure to give the colorless transparent liquid 3',5'-dichloro-2,2,2-trifluoroacetophenone (2.58 g, 48% yield).

References

[1] Patent: CN107353189, 2017, A. Location in patent: Paragraph 0019; 0023
[2] Bulletin of the Chemical Society of Japan, 1997, vol. 70, # 12, p. 3081 - 3090

3',5'-DICHLORO-2,2,2-TRIFLUOROACETOPHENONE synthesis

431-47-0
19752-55-7
130336-16-2
Synthesis of 3',5'-DICHLORO-2,2,2-TRIFLUOROACETOPHENONE from Methyl trifluoroacetate and 1-Bromo-3,5-dichlorobenzene

3',5'-DICHLORO-2,2,2-TRIFLUOROACETOPHENONE Preparation Products And Raw materials

Raw materials

1-Bromo-3,5-dichlorobenzene Perfluoroacetyl fluoride Trifluoroacetyl chloride Ethyl trifluoroacetate 3,5-Dichlorobenzaldehyde
Trifluoroacetyl bromide 1-TRIFLUOROACETYL PIPERIDINE 4-(Trifluoroacetyl)morpholine Methyl trifluoroacetate N,N-DIETHYL-2,2,2-TRIFLUOROACETAMIDE

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Preparation Products

1,3-dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene

3',5'-DICHLORO-2,2,2-TRIFLUOROACETOPHENONE Suppliers

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View Lastest Price from 3',5'-DICHLORO-2,2,2-TRIFLUOROACETOPHENONE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1-(3,5-Dichlorophenyl)-2,2,2-trifluoroethanone pictures 2026-01-04 1-(3,5-Dichlorophenyl)-2,2,2-trifluoroethanone
130336-16-2
 US $0.00-0.00 / kg 1kg 98.0% min 1ton/month Hangzhou ICH Biofarm Co., Ltd
3',5'-DICHLORO-2,2,2-TRIFLUOROACETOPHENONE pictures 2025-12-24 3',5'-DICHLORO-2,2,2-TRIFLUOROACETOPHENONE
130336-16-2
 US $3320.00 / KG 1KG 98.0% 1T Shaanxi Dideu Medichem Co. Ltd
1-(3,5-dichlorophenyl)-2,2,2-trifluoroethanone pictures 2025-04-04 1-(3,5-dichlorophenyl)-2,2,2-trifluoroethanone
130336-16-2
 US $0.00-0.00 / kg 1kg 98% 1Ton Henan Aochuang Chemical Co.,Ltd.

3',5'-DICHLORO-2,2,2-TRIFLUOROACETOPHENONE Spectrum

3',5'-DICHLORO-2,2,2-TRIFLUOROACETOPHENONE(130336-16-2)FT-IR

130336-16-2(3',5'-DICHLORO-2,2,2-TRIFLUOROACETOPHENONE)Related Search:

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Copper(II) chloride dihydrate SODIUM METHACRYLATE Copper(II) sulfate pentahydrate Benzoyl chloride Chalcone
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3',4'-DICHLORO-2,2,2-TRIFLUOROACETOPHENONE 3'-CHLORO-2,2,2-TRIFLUOROACETOPHENONE 3',5'-DICHLORO-2,2,2-TRIFLUOROACETOPHENONE

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3',5'-DICHLORO-2,2,2-TRIFLUOROACETOPHENONE 1-(3,5-DICHLORO-PHENYL)-2,2,2-TRIFLUORO-ETHANONE 1-(3,5-dichlorophenyl)-2,2,2-trifluoro-1-ethanone 1-(3,5-dichlorophenyl)-2,2,2-trifluoroethan-1-one 1-(3,5-DichL uoroethanone Ethanone, 1-(3,5-dichlorophenyl)-2,2,2-trifluoro- )-2,2,2-trifL 3',5'-Dichloro-2,2,2-trifluoroacetophenone （Fluralaner intermediate） Fluralaner-002 2-TRIFLUOROACETOPHENONE 5-DICHLORO-2 2,2,2-Trifluoro-1-(3,5-dichlorophenyl)ethanone, 96% 3',5'-DICHLORO-2,2,2-TRIFLUOROACETOPHENONE 130336-16-2 Fluralaner Impurity 28 3',5' dichloro trifluoro acetophenone 3,5-Dichloro-2,2,2-trifluorophenone 3',5'-Dichloro-2,2,2-trifluoroacetophenone （Fluralaner intermediate） N - [[2- [[[4- (aminoiminomethyl) phenyl] amino] methyl] -1-methyl-1H-benzimidazol-5-yl] carbonyl] - N-2-pyridine-BETA-alanine ethyl ester 3,5-Dichloro-2',2',2'-trifluoroacetophenone 1-(3,5-Dichlorophenyl)-2,2,2-trifluorobenzophenone 3',5'-Dichloro-2,2,2-trifluorobenzophenone 3′,5′-Dichloro-2,2,2-trifluoroacetophenone, CAS 130336-16-2 3 ', 5' - Dichloro-2,2,2-trifluoroacetophenone (intermediate of Frellana) 1-(3,5-dichlorophenyl)-2,2,2-trifluoro-1-ethanonChemicalbooke 1-(3,5-Dichlorophenyl)-2,2,2-trifluoroethanone 98% Acetophenone673 130336-16-2 30336-16-2 1300336-16-2 Intermediates 1