BOC-HYP(BZL)-OH
- CAS No.
- 54631-81-1
- Chemical Name:
- BOC-HYP(BZL)-OH
- Synonyms
- BOC-HYP(BZL);BOC-HYP(BZL)-OH;BOC-L-HYP(BZL)-OH;Boc-Hyp(Bzl)·DCHA;BOC-PRO(4-OBZL)-OH;BOC-HYP(BZL)-OH DCHA;Boc-L-Hyp(Bzl)-OH·DCHA;BOC-HYP(BZL)-OH·DCHA,98%;BOC-HYP(BZL)-OH USP/EP/BP;BOC-HYDROXYPROLINE(BZL)-OH
- CBNumber:
- CB6148544
- Molecular Formula:
- C17H23NO5
- Molecular Weight:
- 321.37
- MDL Number:
- MFCD00037325
- MOL File:
- 54631-81-1.mol
| Product description | Number | Pack Size | Price |
| Boc-Hyp(Bzl)-OH ≥98.0% (HPLC) | 15535 | 5g | $261 |
| Boc-O-benzyl-L-trans-4-hydroxyproline | 264602 | 2g | $360 |
| Boc-O-benzyl-L-trans-4-hydroxyproline dicyclohexylammonium salt 99+% | 236621 | 1g | $179 |
| BOC-HYP(BZL)-OH 95.00% | AAA0000905 | 1G | $154.35 |
| Boc-O-benzyl-L-trans-4-hydroxyproline | FB46922 | 5G | $173 |
| More product size | |||
| Melting point | ~70 °C |
|---|---|
| Boiling point | 461.3±45.0 °C(Predicted) |
| Density | 1.21±0.1 g/cm3(Predicted) |
| storage temp. | Sealed in dry,2-8°C |
| solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. |
| pka | 3.75±0.40(Predicted) |
| form | Powder |
| Appearance | White to off-white Solid |
| optical activity | [α]20/D 40±2°, c = 2% in ethanol |
| BRN | 5296858 |
| Major Application | peptide synthesis |
| InChI | 1S/C17H23NO5/c1-17(2,3)23-16(21)18-10-13(9-14(18)15(19)20)22-11-12-7-5-4-6-8-12/h4-8,13-14H,9-11H2,1-3H3,(H,19,20)/t13-,14+/m1/s1 |
| InChIKey | DGIGGVANZFKXLS-KGLIPLIRSA-N |
| SMILES | CC(C)(C)OC(=O)N1C[C@@H](C[C@H]1C(O)=O)OCc2ccccc2 |
| CAS DataBase Reference | 54631-81-1(CAS DataBase Reference) |
| UNSPSC Code | 12352200 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P301+P312-P302+P352-P304+P340-P305+P351+P338 |
| PPE | Eyeshields, Gloves, type N95 (US) |
| WGK Germany | 3 |
| Storage Class | 13 - Non Combustible Solids |
BOC-HYP(BZL)-OH price More Price(33)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 15535 | Boc-Hyp(Bzl)-OH ≥98.0% (HPLC) | 54631-81-1 | 5g | $261 | 2022-05-15 | Buy |
| Usbiological | 264602 | Boc-O-benzyl-L-trans-4-hydroxyproline | 54631-81-1 | 2g | $360 | 2021-12-16 | Buy |
| Usbiological | 236621 | Boc-O-benzyl-L-trans-4-hydroxyproline dicyclohexylammonium salt 99+% | 54631-81-1 | 1g | $179 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | AAA0000905 | BOC-HYP(BZL)-OH 95.00% | 54631-81-1 | 1G | $154.35 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FB46922 | Boc-O-benzyl-L-trans-4-hydroxyproline | 54631-81-1 | 5G | $173 | 2021-12-16 | Buy |
BOC-HYP(BZL)-OH Chemical Properties,Uses,Production
Chemical Properties
White to off-white powder
Uses
Boc-Hyp(Bzl)-OH, is an amino acid building block used in peptide synthesis. With a growing peptide drug market the fast, reliable synthesis of peptides is of great importance.
reaction suitability
reaction type: Boc solid-phase peptide synthesis
Synthesis
136024-60-7
40350-83-2
General procedure for the synthesis of 4-(benzyloxy)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid from 1-(tert-butyl) 2-methyl (2S,4R)-4-(benzyloxy)pyrrolidine-1,2-dicarboxylic acid ester: lithium hydroxide was added to a mixture of THF and H2O (60 mL, 2:1, v/v/v/v/v) of compound 2 (3.45 g, 10.29 mmol) monohydrate (1.29 g, 30.87 mmol). The reaction mixture was stirred at room temperature for 3 hours. After the completion of the reaction was monitored by TLC, the reaction mixture was concentrated under reduced pressure, acidified to pH < 7 with 1N hydrochloric acid solution and subsequently extracted with ethyl acetate (3 x 30 mL). The organic layers were combined, washed with saturated sodium chloride solution (30 mL), dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give the crude product. The crude product was purified by grinding with pentane (20 mL) to give compound 3 (3.21 g, 97% yield) in white solid form. Mass spectrum (ESI) m/z 322 [M+H]+.
References
[1] Patent: US9994614, 2018, B2. Location in patent: Page/Page column 51; 52; 53
[2] Patent: WO2012/146666, 2012, A1. Location in patent: Page/Page column 206
BOC-HYP(BZL)-OH Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29735 | 60 |
| GenicBio Limited | +86-21-37621270 | service@genicbio.com | CHINA | 991 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29838 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
View Lastest Price from BOC-HYP(BZL)-OH manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | BOC-HYP(BZL)-OH
54631-81-1
|
US $100.00 / KG | 1KG | 99% | Customized | Career Henan Chemical Co |
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- BOC-HYP(BZL)-OH
54631-81-1
- US $100.00 / KG
- 99%
- Career Henan Chemical Co
