(S)-ROSCOVITINE
- CAS No.
- 186692-45-5
- Chemical Name:
- (S)-ROSCOVITINE
- Synonyms
- Roscovitine, (S)-Isomer - CAS 186692-45-5 - Calbiochem;(2S)-2-[[9-(1-Methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol;1-Butanol, 2-[[9-(1-methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-, (2S)-
- CBNumber:
- CB71498962
- Molecular Formula:
- C19H26N6O
- Molecular Weight:
- 354.45
- MDL Number:
- MFCD02266402
- MOL File:
- 186692-45-5.mol
| Product description | Number | Pack Size | Price |
| (S)-Roscovitine ≥99%(NMR) | AG-MR-C0002-M005 | 5mg | $90 |
| (S)-ROSCOVITINE 95.00% | KIN0000007 | 1MG | $456 |
| (S)-ROSCOVITINE 95.00% | KIN0000007 | 5MG | $802.38 |
| Melting point | 103-106℃ |
|---|---|
| Density | 1.25 |
| storage temp. | -20C |
| form | White solid |
| color | White to off-white |
| FDA UNII | 8C43G94891 |
(S)-ROSCOVITINE price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Adipogen Life Sciences | AG-MR-C0002-M005 | (S)-Roscovitine ≥99%(NMR) | 186692-45-5 | 5mg | $90 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000007 | (S)-ROSCOVITINE 95.00% | 186692-45-5 | 1MG | $456 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000007 | (S)-ROSCOVITINE 95.00% | 186692-45-5 | 5MG | $802.38 | 2021-12-16 | Buy |
(S)-ROSCOVITINE Chemical Properties,Uses,Production
Uses
(S)-Roscovitine ((S)-Seliciclib; (S)-CYC202) is a potent and cross the blood-brain barrier CDKs inhibitor. (S)-Roscovitine shows neuroprotective efficacy. (S)-Roscovitine has the potential for the research of stroke[1][2].
in vivo
(S)-Roscovitine (25 mg/kg; i.p.; 15 min before and 1 hr after pMCAo) shows neuroprotective efficacy in an adult mouse model of permanent MCAo (middle cerebral artery occlusion) [2].
| Animal Model: | 20-25 g, P60 male C57 b/6 mice[2] |
| Dosage: | 25 mg/kg |
| Administration: | I.p.; at 15 min before and 1 hr after pMCAo |
| Result: | Decreased of the total infarct volume. |
IC 50
CDK1: ≤1 μM (IC50); CDK2: ≤1 μM (IC50); CDK5: ≤1 μM (IC50); CDK7: ≤1 μM (IC50); CDK9: ≤1 μM (IC50)
storage
+4°C
References
[1] Le Roy L, et al. Cellular and Molecular Mechanisms of R/S-Roscovitine and CDKs Related Inhibition under Both Focal and Global Cerebral Ischemia: A Focus on Neurovascular Unit and Immune Cells. Cells. 2021 Jan 8;10(1):104. DOI:10.3390/cells10010104
[2] Menn B, et al. Delayed treatment with systemic (S)-roscovitine provides neuroprotection and inhibits in vivo CDK5 activity increase in animal stroke models. PLoS One. 2010 Aug 12;5(8):e12117. DOI:10.1371/journal.pone.0012117
(S)-ROSCOVITINE Preparation Products And Raw materials
Raw materials
Preparation Products
(S)-ROSCOVITINE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9803 | 58 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 8011 | 55 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29357 | 58 |
| Enzo Biochem Inc | Enzo Biochem Inc. 13797054060 | Enzoname@qq.com | China | 6174 | 58 |
| Biosynth Biological Technology (Suzhou) Co Ltd | 51288865780 | sales@biosynth.com | China | 6051 | 58 |
| Qingdao Everest Technology & Trade Co., Ltd. | 13792478491 | CHINA | 161 | 58 |
