1-(5-BROMO-2-FLUOROPHENYL)ETHANONE
- CAS No.
- 198477-89-3
- Chemical Name:
- 1-(5-BROMO-2-FLUOROPHENYL)ETHANONE
- Synonyms
- 1-(5-broMo-2-fluorophenyl)ethan-1-one;2-Fluoro-5-bromoacetophenone;5-BROMO-2-FLUOROPHENYLETHANONE;5'-Bromo-2'-fluoroacetophenone;5‘-BroMo-2'-fluoroacetophenone;1-(5-BROMO-2-FLUOROPHENYL)ETHANONE;5-BroMo-2-fluorophenyl)-1-ethanone;5'-Bromo-2'-fluoroacetophenone,98%;1-(5-BROMO-2-FLUORO-PHENYL)-ETHANON;Ethanone, 1-(5-broMo-2-fluorophenyl)-
- CBNumber:
- CB72458011
- Molecular Formula:
- C8H6BrFO
- Molecular Weight:
- 217.04
- MDL Number:
- MFCD11226880
- MOL File:
- 198477-89-3.mol
| Product description | Number | Pack Size | Price |
| 1-(5-Bromo-2-fluorophenyl)-1-ethanone | KOB0158 | 1 g | $330 |
| 5'-Bromo-2'-fluoroacetophenone >98.0%(GC) | B5237 | 1g | $34 |
| 5'-Bromo-2'-fluoroacetophenone >98.0%(GC) | B5237 | 5g | $132 |
| 5''-Bromo-2''-fluoroacetophenone | B691878 | 1g | $75 |
| 1-(5-Bromo-2-fluorophenyl)-1-ethanone 95+% | 054340 | 5g | $44 |
| More product size | |||
| Melting point | 42 °C |
|---|---|
| Boiling point | 251℃ |
| Density | 1.535 |
| Flash point | 106℃ |
| storage temp. | Sealed in dry,Room Temperature |
| form | Solid |
| color | White to Orange to Green |
| Water Solubility | Slightly soluble in water. |
| InChI | InChI=1S/C8H6BrFO/c1-5(11)7-4-6(9)2-3-8(7)10/h2-4H,1H3 |
| InChIKey | XNRQIHIOKXQSPG-UHFFFAOYSA-N |
| SMILES | C(=O)(C1=CC(Br)=CC=C1F)C |
| UNSPSC Code | 12352200 |
| NACRES | NA.21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| WGK Germany | WGK 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2914390090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Irrit. 2 |
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| NFPA 704 |
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1-(5-BROMO-2-FLUOROPHENYL)ETHANONE price More Price(48)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | KOB0158 | 1-(5-Bromo-2-fluorophenyl)-1-ethanone | 198477-89-3 | 1 g | $330 | 2025-07-31 | Buy |
| TCI Chemical | B5237 | 5'-Bromo-2'-fluoroacetophenone >98.0%(GC) | 198477-89-3 | 1g | $34 | 2025-07-31 | Buy |
| TCI Chemical | B5237 | 5'-Bromo-2'-fluoroacetophenone >98.0%(GC) | 198477-89-3 | 5g | $132 | 2025-07-31 | Buy |
| TRC | B691878 | 5''-Bromo-2''-fluoroacetophenone | 198477-89-3 | 1g | $75 | 2021-12-16 | Buy |
| Matrix Scientific | 054340 | 1-(5-Bromo-2-fluorophenyl)-1-ethanone 95+% | 198477-89-3 | 5g | $44 | 2021-12-16 | Buy |
1-(5-BROMO-2-FLUOROPHENYL)ETHANONE Chemical Properties,Uses,Production
Uses
5'-Bromo-2'-fluoroacetophenone is an intermediate used in pharmaceuticals.
Preparation
Synthesis of 1-(5-Bromo-2-fluorophenyl)ethanone: In a dry flask, a solution of 5-bromo-2-fluoro-N-methoxy-N-methylbenzamide (3.73 g, 14.2 mmol) in tetrahydrofuran (24 mL) was treated dropwise with a solution of methyl magnesium chloride (3 M in THF, 5.69 mL, 17 mmol) at 12–16 °C. After complete addition, the reaction mixture was heated to reflux. After 20 min, the resulting white suspension was quenched with saturated ammonium chloride solution (25 mL) under ice cooling. The mixture was then diluted with ethyl acetate (50 mL), and the aqueous layer was separated and re-extracted with ethyl acetate (50 mL). The combined organic layers were washed with brine (20 mL), dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The crude product was purified to afford 1-(5-bromo-2-fluorophenyl)ethanone as a pale yellow solid (2.6 g, 84% yield), with an Rf = 0.55 (silica gel, eluent: heptane/ethyl acetate = 4:1).
Synthesis
910912-20-8
75-16-1
198477-89-3
Synthesis of 1-(5-bromo-2-fluorophenyl)ethanone (15): To a stirred solution of 5-bromo-2-fluoro-N-methoxy-N-methylbenzamide (14) (106 g, 404 mmol) in anhydrous tetrahydrofuran (THF) (1.7 L) was slowly added, under nitrogen protection and at 0 °C, an ether solution of methylmagnesium bromide (3.0 M, 270 mL, 808 (3.0 M, 270 mL, 808 mmol). After addition, the reaction was continued to be stirred at 0 °C for 6.5 hours. After completion of the reaction, the reaction solution was slowly poured into 2N hydrochloric acid (1 L) and gradually warmed to room temperature. The reaction mixture was extracted with ethyl acetate (2 x 1 L). The organic phases were combined, washed sequentially with saturated aqueous sodium bicarbonate (500 mL) and brine (500 mL), dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure to afford the target product 15 (85.2 g, 97% yield) as an orange oil. The product was confirmed by 1H NMR (300 MHz, CDCl3): δ 7.98 (dd, J = 6.4, 2.6 Hz, 1H), 7.61 (ddd, J = 8.7, 4.3, 2.6 Hz, 1H), 7.05 (dd, J = 10.4, 8.7 Hz, 1H), 2.64 (d, J = 4.9 Hz, 3H); ESI MS m/ z 217 [M + H]+.
References
[1] Patent: WO2011/44184, 2011, A1. Location in patent: Page/Page column 103-104
1-(5-BROMO-2-FLUOROPHENYL)ETHANONE Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20126 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29735 | 60 |
| Hi-Tech Chemistry Corp | 0519-86626038 | yuhh@hitechem.com | CHINA | 810 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21595 | 55 |
| Fluoropharm Co., Ltd. | +86-0571-85586753 +86-13336034509 | sales@fluoropharm.com | China | 1445 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29830 | 58 |
| Shanghai Arbor Chemical Co., Ltd. | 021-60451682 | act@arborchemical.com | CHINA | 904 | 58 |
| Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 | sales@ansciepchem.com | CHINA | 4241 | 58 |
| Nanjing Dolon Biotechnology Co.,Ltd. | 18905173768 | 52513593@qq.com | CHINA | 2972 | 58 |
View Lastest Price from 1-(5-BROMO-2-FLUOROPHENYL)ETHANONE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2025-09-25 | 1-(5-Bromo-2-fluorophenyl)ethanone
198477-89-3
|
US $200.00-1.00 / KG | 1KG | 99%, 99.5% Sublimated | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | |
 |
2019-07-12 | 1-(5-BROMO-2-FLUOROPHENYL)ETHANONE
198477-89-3
|
US $1.00 / KG | 1KG | 99% | 100kg | Career Henan Chemical Co |
-
- 1-(5-Bromo-2-fluorophenyl)ethanone
198477-89-3
- US $200.00-1.00 / KG
- 99%, 99.5% Sublimated
- Henan Fengda Chemical Co., Ltd
-
- 1-(5-BROMO-2-FLUOROPHENYL)ETHANONE
198477-89-3
- US $1.00 / KG
- 99%
- Career Henan Chemical Co
