GDF-8

GDF-8 C화학적 특성, 용도, 생산

개요

Myostatin (GDF-8), a member of the TGF-beta superfamily of growth and differentiation factors, is most well-known as a potent suppressor of muscle growth, development, and regeneration. It is highly expressed in skeletal muscle, and myostatin loss-of-function leads to doubling skeletal muscle mass. Mice lacking myostatin show a significant increase in muscle mass, and congenital absence of myostatin is associated with increased muscle mass in humans and dogs. It has also been shown that factors which inhibit myostatin, such as follistatin, can improve muscle regeneration and decrease fibrosis in injured muscles[1].

용도

Myostatin (GDF-8) is a secreted protein that is a potent inhibitor of muscle growth and development, whereas GDF-8 is also expressed early in the fracture healing process. Thus, blocking GDF-8 signalling in the injured limb improves fracture healing and promotes muscle regeneration. These data suggest that GDF-8 inhibitors may be effective in improving wound repair in orthopaedic trauma and extremity injuries.

Physiological effects

GDF-8 functions as a specific negative regulator of skeletal muscle growth. It forms homodimers linked by disulfide bonds and inhibits WFIKKN2 activity through interaction. GDF-8 also interacts with FST3, playing a regulatory role in skeletal muscle growth modulation.

GDF-8 준비 용품 및 원자재

원자재

준비 용품

GDF-8 공급 업체

공급자	전화	이메일	국가	제품 수	이점
Qingdao Xinli Technology Development Co., Ltd.	+8616632313095	xinlikeji01@qdxlchem.com	China	124	58
Shanghai Affida new material science and technology center	+undefined15081010295	admin@oudaxin.com	China	114	58
Hubei KDG Web Science&Technology Co., Ltd	18672314556 +8618672314556	sales@kdg-tech.com	China	933	58
Hebei Lutong Import and Export Co., Ltd	+8618131159658	judy@hbjbrh.com	China	70	58
Hainan Fubai Trading Co., LTD	+undefined852-57423927	13313004729@163.com	China	103	58
zhuzhou dingcheng meihei comestic co.,ltd	+8618873369619	dingchengbusiness8@163.com	China	260	58
Hebei Zhuanglai Chemical Trading Co.,Ltd	+8613343047651	admin@zlchemi.com	China	3692	58
Hebei Ganmiao New material Technology Co., LTD	+86-17332992504	sales8@hbganmiao.com	China	300	58
.GZ HONESTCHEM CO.,LTD	+8615013270415	honestchemical@foxmail.com	China	285	58
Shanghai Longyu Biotechnology Co., Ltd.	+8619521488211	info@longyupharma.com	China	2541	58

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