Trifludimoxazin;Trifludimoxazin, 10 mM in DMSO;Trifludimoxazin,inhibit,Inhibitor;Trifludimoxazin 100 μg/mL in Acetonitrile;1,5-dimethyl-6-thioxo-3-(2,2,7-trifluoro-3-oxo-4-(prop-2-ynyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)-1,3,5-triazinane-2,4-dione;1,5-dimethyl-6-thioxo-3-(2,2,7-trifluoro-3-oxo-4-(prop-2-yn-1-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)-1,3,5-triazinane-2,4-dione;1,3,5-Triazine-2,4(1H,3H)-dione, dihydro-1,5-dimethyl-6-thioxo-3-[2,2,7-trifluoro-3,4-dihydro-3-oxo-4-(2-propyn-1-yl)-2H-1,4-benzoxazin-6-yl]-
장기간 또는 반복 노출되면 장기(또는, 영향을 받은 알려진 모든 장기를 명시)에 손상을 일으킬 수 있음
특정 표적장기 독성 - 반복 노출
구분 2
경고
P260, P314, P501
H400
수생생물에 매우 유독함
수생 환경유해성 물질 - 급성
구분 1
경고
P273, P391, P501
H410
장기적 영향에 의해 수생생물에 매우 유독함
수생 환경유해성 물질 - 만성
구분 1
경고
P273, P391, P501
예방조치문구:
P260
분진·흄·가스·미스트·증기·...·스프레이를 흡입하지 마시오.
P273
환경으로 배출하지 마시오.
P314
불편함을 느끼면 의학적인 조치·조언을 구하시오.
P391
누출물을 모으시오.
P501
...에 내용물 / 용기를 폐기 하시오.
trifludimoxazin C화학적 특성, 용도, 생산
Synthesis
374.6 g (2.2647 mol) 1,1'-carbonyldiimidazole (98%), 76.4 g (0.7549 mol) triethyamine and 2437 g ethyl acetate were initially charged at 20°C in a stirred vessel. 200 g (0.7549 mol) 6- amino-2,2,7-trifluoro-4-prop-2-yny4H-benzo[1,4]oxazin-3-one (96,7%) were added in portions. The reaction mixture was heated to 55°C At this temperature 95.4 g (0,9064 mol) N,N'-dimethylthiourea (99%) were added. The reaction mixture was stirred at 75-77°C for 25 hours and then poured to a mixture of 2680 ml ice/water and 460 ml hydrochloric acid (32%). The phases were separated and the aqueous phase was extracted twice with 775 ml ethyl acetate. The combined organic phases were dried with Na2SO4 and concentrated to yield 322.9 g. The residue was dissolved in 5970 ml methanol at 65°C 5600 ml methanol were disted off and the remaining suspension was cooled to 0°C. The solid was filtered off and washed with 100 ml cold methanol. The wet solid was dried in a vacuum cabinet at 50°C/10mbar over 24 hours. the desired product trifludimoxazin (determined by quant. HPLC; HPLCmethod A) were isolated. yield 271.0 g, 86.9%.[2]
참고 문헌
[1] Asher, Brady Scott, et al. Vertical mobility, soil adsorption, and cotton tolerance to three Protoporphyrinogen oxidase (PPO) inhibiting herbicides in three West Texas soils. Texas tech university. [2] WOLF B, MAYWALD V,VOGELBACHER UJ, et al. Process formanufacturing triazinon-benzoxazizones: wo，2013092858 [P].2013-06-27.
