Calcitonin is a single-chain polypeptide consisting of 32 amino acid residues.
Calcitonins as obtained from different species are identical at seven of the first nine residues,
contain Gly at position 28, and all terminate with Pro-NH2. The C-terminal proline amide (ProNH2) is very important for the biological function of CT, as is the disulfide bridge between Cys
residues at positions 1 and 7. In contrast, the residues from 10 through 27 can be varied and
seem to influence CT's potency as well as its duration of action. Salmon CT differs from human
CT at 16 amino acid residues.
화학적 성질
White or almost white powder.
용도
Calcitonin salmon can be used for calcitonin receptor/cAMP assay for assessing the presence of calcitonin receptors expressed by TRAP+ cells.The product can also be used as a test compound for studying as well as comparing the impact of calcitonin gene related peptide (CGRP) and salmon calcitonin (sCT) on gastric mucosal barrier in rats exposed to cold + restraint stress (CRS).
Clinical Use
Only salmon CT is commercially available for medical use, because on a weight basis, it is
approximately 45-fold more potent than human CT. Salmon CT, in parenteral form, is approved
for treating Paget's disease of bone (generally seen in older persons; involves increased bone
resorption and softening of bones), postmenopausal osteoporosis, and hypercalcemia of malignancy
(multiple myeloma or advanced breast carcinoma). Salmon CT also is available in a nasal spray
formulation, which is used exclusively in the treatment of postmenopausal osteoporosis.
