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5-Chlorothiophene-2-carboxylic acid

5-Chlorothiophene-2-carboxylic acid 구조식 이미지

카스 번호:: 24065-33-6

상품명:: 5-Chlorothiophene-2-carboxylic acid

동의어(영문):: 5-Chlorothiophene-2-carboxylic;5-chloro-2-thiophenecarboxylicaci;5-Chlorothiophen-2-carboxylic acid;5-CHLORO-2-THIOPHENECARBOXYLIC ACID;NSC 14776;AKOS B000092;Rivaroxaban F;2-Amino-9-picoline;RARECHEM AL BE 0303;TIMTEC-BB SBB003937

CBNumber:: CB3189269

분자식:: C5H3ClO2S

포뮬러 무게:: 162.59

MOL 파일:: 24065-33-6.mol

MSDS 파일:: SDS

속성

안전

용도

공급 업체 885

5-Chlorothiophene-2-carboxylic acid 속성

녹는점: 154-158 °C(lit.)

끓는 점: 287.0±20.0 °C(Predicted)

밀도: 1.466 (estimate)

저장 조건: Keep in dark place,Sealed in dry,Room Temperature

용해도: DMSO(약간 용해됨), 메탄올(약간 용해됨)

산도 계수 (pKa): 3.32±0.10(Predicted)

물리적 상태: 가루

색상: 크림색

BRN: 118361

InChI: InChI=1S/C5H3ClO2S/c6-4-2-1-3(9-4)5(7)8/h1-2H,(H,7,8)

InChIKey: QZLSBOVWPHXCLT-UHFFFAOYSA-N

SMILES: C1(C(O)=O)SC(Cl)=CC=1

CAS 데이터베이스: 24065-33-6(CAS DataBase Reference)

NIST: 5-Chloro-2-thiophenecarboxylic acid(24065-33-6)

안전

위험 및 안전 성명
위험 및 사전주의 사항 (GHS)

위험품 표기	Xi
위험 카페고리 넘버	36-43-36/37/38
안전지침서	26-36-37/39
WGK 독일	3
RTECS 번호	XM8400000
위험 등급	IRRITANT
HS 번호	29349990

그림문자(GHS):

신호 어:

Warning

유해·위험 문구:

암호	유해·위험 문구	위험 등급	범주	신호 어	그림 문자	P- 코드
H317	알레르기성 피부 반응을 일으킬 수 있음	피부 과민성 물질	구분 1	경고		P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H319	눈에 심한 자극을 일으킴	심한 눈 손상 또는 자극성 물질	구분 2A	경고		P264, P280, P305+P351+P338,P337+P313P

예방조치문구:

P280	보호장갑/보호의/보안경/안면보호구를 착용하시오.
P302+P352	피부에 묻으면 다량의 물로 씻으시오.
P305+P351+P338	눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.

NFPA 704

	0
2		0

5-Chlorothiophene-2-carboxylic acid C화학적 특성, 용도, 생산

개요

5-Chlorothiophene-2-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science-related research. It is also used as a ligand to synthesise the New Mono and Binuclear Ruthenium(II) Complexes[1].

화학적 성질

White to light yellow crystal powder

용도

5-Chlorothiophene-2-carboxylic acid can be used in the synthesis of the following:

rivaroxaban, an oxazolidinone derivative used in the treatment of thromboembolic disorders
5-chloro-4-nitrothiophene-2-carboxylic acid, which can be used in the synthesis of thieno[2,3-b][1,4]thiapezine-5-ones

Synthesis

The compound 5-chlorothiophene-2-carboxylic acid is a crucial intermediate in the synthesis of rivaroxaban. Due to its significance, numerous researchers have investigated various methods of synthesizing it. The synthesis of this compound involves the utilization of different starting materials, namely, 2-chlorothiophene, 2-chloro-5-bromothiophene, and 5-chloro-2-acetylthiophene, depending on the specific approach employed. undefined

1. This method takes 2-chlorothiophene as an initial raw material, carrying out Friedel-crafts acylation with trichloroacetyl chloride under the action of aluminum trichloride to generate 2-trichloroacetyl-5-chlorothiophene, and then carrying out liquid alkali hydrolysis to obtain a target product.
2. This method reacts 5-chloro-2-bromothiophene with magnesium to generate a Grignard reagent, introducing carbon dioxide for inserting carbonyl and performing acid-base treatment to obtain a product.
3. 5-chloro-2-acetylthiophene is used as a raw material and is oxidized by sodium chlorite and potassium dihydrogen phosphate system to obtain a target compound.

5-Chlorothiophene-2-carboxylic acid 준비 용품 및 원자재

원자재

클로로(2-)티오펜 질소 디클로로티오펜 디에틸에테르 황산 부틸리튬 탄산나트륨(경회)

준비 용품

4-broMo-5-클로로티오펜-2-카르복실산 2-티오펜카복사미드,5-클로로-N-메틸-실험적특성 5-CHLOROTHIOPHENE-2-CARBONYL CHLORIDE 3-(5-클로로-티오펜-2-YL)-3-옥소-프로피오니트릴

5-Chlorothiophene-2-carboxylic acid 공급 업체

글로벌( 885)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Shanghai Rochi Pharmaceutical Co.,Ltd.	21-38751876 +8615000076078	info@rochipharma.com	China	505	58
Beijing Mediking Biopharm Co., Ltd	+undefined15901403431	sales01@mediking.cn	China	150	58
Suzhou Nordica Biopharma CO.,LTD	+86-18136148818 +86-18567353071	3537297702@qq.com	China	299	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8768	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-13131129325	sales1@chuanghaibio.com	China	5249	58
Henan Bao Enluo International TradeCo.，LTD	+86-17331933971	deasea125996@gmail.com	China	2472	58
Anhui Ruihan Technology Co., Ltd	+8617756083858	daisy@anhuiruihan.com	China	973	58
airuikechemical co., ltd.	+86-18353166132	sales02@airuikechemical.com	China	983	58
Hebei Zhuanglai Chemical Trading Co.,Ltd	+8613343047651	admin@zlchemi.com	China	3692	58
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD	+86-15350851019; +8615350851019	admin@86-ss.com	China	999	58

5-Chlorothiophene-2-carboxylic acid 관련 검색:

2-클로로-5-티오펜카르복스알데히드 4-(4-니트로페닐)모르폴린-3-원 (S)-2-(3-클로로-2-히드록시프로필)이소인돌린-1,3-디온 4,5-디클로로티오펜-2-카르복실산 클로로(2-)티오펜 메틸3-클로로티오펜-2-카복실레이트 5-클로로티오펜-3-카복시산 4-클로로티오펜-2-카복시산 5-클로로-4-니트로티오펜-2-카르복실산 3,4,5-트리클로로티오펜-2-카르복실산 4-아미노-5-클로로티오펜-2-카르복실산메틸에스테르 5-클로로-4-니트로티오펜-2-카르복실산메틸에스테르 Rivaroxaban Impurity 43 2-[(2R)-2-Hydroxy-3-[[4-(3-oxo-4-Morpho linyl)phenyl]aMino]propyl]-1H-isoindole-1 ,3(2H)-dione AcetaMide, N-[[(5S)-2-oxo-3-[4-(3-oxo-4-Morpholinyl)phenyl]-5-oxazolidinyl]Methyl]- 2-Thiophenecarboxylic acid 4-(4-AMINOPHENYL)MORPHOLIN-3-ONE Urea, N,N'-bis[[(5S)-2-oxo-3-[4-(3-oxo-4-Morpholinyl)phenyl]-5-oxazolidinyl]Methyl]-