Thymulin

Thymulin 구조식 이미지
카스 번호:
63958-90-7
상품명:
Thymulin
동의어(영문):
STF;Thymulin;Nonathymulin;SERUM THYMIC;THYMIC FACTOR;Zinc Thymulin;thymulin-Zinc;ThymulinAcetate;Thymalin/Thymulin;Thymulin(Thymalin)
CBNumber:
CB3485859
분자식:
C33H54N12O15
포뮬러 무게:
858.85
MOL 파일:
63958-90-7.mol

Thymulin 속성

끓는 점
1658.9±65.0 °C(Predicted)
밀도
1.417±0.06 g/cm3(Predicted)
저장 조건
−20°C
용해도
탈이온수: 가용성
산도 계수 (pKa)
3.08±0.10(Predicted)
물리적 상태
동결건조된 분말
색상
하얀색
시퀀스
Pyr-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn-OH
InChIKey
LIFNDDBLJFPEAN-BPSSIEEOSA-N
SMILES
C(O)(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@@H]1CCC(=O)N1

안전

WGK 독일 3

Thymulin C화학적 특성, 용도, 생산

개요

Nonathymulin, also known as Serum Thymic Factor, is a synthetic thymic peptide hormone. It is a thymus-dependent nonapeptide found in normal blood. Stimulates the formation of E rosettes and is believed to be involved in T-cell differentiation. It also acts as an effector on proinflammatory mediators/cytokines.

생물학적 활성

Thymulin (Nonathymulin) has immunomodulatory and anti-inflammatory effects. Thymulin treatment significantly reduced CFA-induced thermal hyperalgesia and paw edema. In addition, molecular studies showed that it also reduced CFA-induced microglial activation, phosphorylation of p38 MAPK, and production of pro-inflammatory cytokines (TNF-α, IL-6) in the spinal cord. This effect may be mediated by inhibiting the production of inflammatory mediators in spinal microglia and the central nervous system, which seems to be related to the ability of thymulin to reduce p38 MAPK phosphorylation[1].

Thymulin 준비 용품 및 원자재

원자재

준비 용품


Thymulin 공급 업체

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