Gonadorelin acetate

Gonadorelin acetate 속성

Gonadorelin acetate C화학적 특성, 용도, 생산

개요

Gonadorelin acetate is a synthetic version of the naturally occurring gonadotropin-releasing hormone (GnRH). It’s a decapeptide (composed of 10 amino acids) that interacts primarily with the pituitary gland. When administered, it stimulates the pituitary’s gonadotrope cells to release two key reproductive hormones:
Luteinizing hormone (LH)；
Follicle-stimulating hormone (FSH)；
Due to its ability to influence reproductive hormone production, it’s used medically to treat various reproductive disorders. Gonadorelin acetate has multiple indications, including for males and females with congenital hypogonadotropic hypogonadism and females with functional HA. An example of functional HA is the “female athlete triad”, in which they lose their menses. Gonadorelin acetate is also used for women with infertility (idiopathic fertility or infertility related to PCOS) who do not respond to clomid or letrozole. At this point, patients can either do gonadotropin therapy with controlled ovarian hyperstimulation (“essentially IVF [in vitro fertilization]”) or undergo FSH therapy (ovulation induction therapy). However, some patients are deficient in LH, which is responsible for making estradiol. In this case, solo therapies such as Gonal-F? (follitropin alfa) or prominent FSH treatments are insufficient, and patients need to utilize combination FSH and hCG therapies or human menopausal gonadotropins (HMG, “which is the combined FSH and LH”) instead.

용도

Luteinizing hormone releasing hormone human acetate salt has been used:

• for synchronization of the ovulations
• for pre-absorption of the anti-GnRH antibody in staining procedures
• to study pituitary sensitivity to GnRH in presence of endocrine disrupting compound

주요 응용

Gonadorelin acetate is widely used in the diagnosis of central precocious puberty.

Biochem/physiol Actions

Hypothalamic peptide that stimulates release of gonadotrophins from anterior pituitary, thus regulating reproductive functions.

부작용

Gonadorelin acetate is usually considered a safe medication. However, severe anaphylactic shock may occur after intravenous administration, manifested by loss of consciousness and tonic convulsions of the arms and legs; prompt treatment with epinephrine, diphenhydramine and fluids restores vital signs within 30 minutes. Therefore, it is recommended that these drugs be administered in an environment that is capable of handling systemic reactions.

Gonadorelin acetate 준비 용품 및 원자재

원자재

준비 용품

Gonadorelin acetate 공급 업체

공급자	전화	이메일	국가	제품 수	이점
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8615965530500	nickzhang@hangyubiotech.com	China	8510	58
Strong peptide cross-border e-commerce Co. LTD	+undefined13930052870	qt01@qiangtaipharm.com	China	84	58
Shandong Huizhihan Supply Chain Co., Ltd	+86-13363081709 +86-13363000288	3957328362@qq.com	China	115	58
Adachibio Inc.	+81-8027837258; +8108027837258	sales@adachibio.com	Japan	992	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21612	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29847	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10405	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28172	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49975	58
Hebei Yanxi Chemical Co., Ltd.	+8618531123677	faithe@yan-xi.com	China	5853	58

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