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N-BOC-아미노-피페리디닐-1,1-카르복실산 C화학적 특성, 용도, 생산
화학적 성질
White to off-white crystalline powder
용도
N-Boc-amino-piperidinyl-1,1-carboxylic acid is used in pharmaceutical synthesis.
Synthesis
The synthesis of N-BOC-amino-piperidinyl-1,1-carboxylic acid usually starts with piperidine-4-carboxylic acid. Sodium bicarbonate and di-tert-butyl dicarbonate (Boc₂O) are added to the reaction system, and the amino protection reaction is carried out in a solvent such as tetrahydrofuran (THF) or 1,4-dioxane. The reaction is stirred at room temperature for several hours until the reaction is completed. Subsequently, the crude product is obtained by steps such as ethyl acetate extraction, pH adjustment of the aqueous phase, drying of the organic phase and reduced pressure concentration, and then purified by column chromatography using a mixed solvent of ethyl acetate and n-hexane as an eluent to finally obtain a high-purity target compound.
