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| | Methyl 4-(aminomethyl)benzoate Basic information |
| | Methyl 4-(aminomethyl)benzoate Chemical Properties |
| Melting point | 243 °C (dec.)(lit.) | | Boiling point | 278.7±23.0 °C(Predicted) | | density | 1.121±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C | | pka | 8.67±0.10(Predicted) | | Appearance | White to off-white Solid | | CAS DataBase Reference | 18469-52-8(CAS DataBase Reference) |
| | Methyl 4-(aminomethyl)benzoate Usage And Synthesis |
| Uses | Methyl 4-aminomethylbenzoate is mainly used as an intermediate in organic synthesis, especially in the fields of medicine and chemical research. | | Synthesis | Thionyl chloride (473 g, 3.97 mol) was added slowly and dropwise to a solution of 4-(aminomethyl)benzoic acid (300 g, 1.98 mol) in methanol (5 L). The reaction mixture was heated and refluxed for 6 h. After completion of the reaction, the solvent was removed by distillation under reduced pressure to give the crude product. The crude product was purified by acid-base treatment to finally obtain methyl 4-(aminomethyl)benzoate (300 g, 92% yield) in liquid form. | | References | [1] Patent: US2008/51397, 2008, A1. Location in patent: Page/Page column 23
[2] Patent: US2007/149802, 2007, A1. Location in patent: Page/Page column 2-3
[3] Patent: WO2005/12280, 2005, A1. Location in patent: Page/Page column 51-52
[4] Patent: EP1541549, 2005, A1. Location in patent: Page/Page column 25; 42
[5] European Journal of Inorganic Chemistry, 2013, # 7, p. 1149 - 1156 |
| | Methyl 4-(aminomethyl)benzoate Preparation Products And Raw materials |
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