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18162-48-6872-50-4Methylene ChloridenaphthaleneTHFTitanium Dioxide
ChemicalBook CAS DataBase List 5-BROMOBENZO[B]THIOPHENE
4923-87-9

5-BROMOBENZO[B]THIOPHENE synthesis

12synthesis methods
5-Bromobenzothiophene is a thiophene derivative and can be used as a pharmaceutical intermediate. It can be synthesized by ring-closure reaction of 1-Bromo-4-[(2,2-diethoxyethyl)thio]benzene with PPA in chlorobenzene.
Acetaldehyde, 2-[(4-bromophenyl)thio]-

105126-89-4
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5-BROMOBENZO[B]THIOPHENE

4923-87-9
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Yield:4923-87-9 105 g

Reaction Conditions:

with phosphorus pentoxide in toluene at 80 - 125; for 47 h;

Steps:

4.2

(2) Add 600ml of toluene and 50g of polyphosphoric acid into a 2L four-necked flask, stir and raise the temperature to 80°C, Add 50g of phosphorus pentoxide, and then increase the temperature to 115-120°C, Start slowly adding step intermediates while controlling the kettle temperature at 120-125°C. It takes 45 hours. After the addition is complete, keep it at the same temperature for 2 hours. The reaction is complete. Cool down to 50°C, add 200g water to the reaction solution, separate into layers, and take the organic layer Under reduced pressure distillation, 105 g of 5-bromobenzothiolane was obtained.

References:

CN111423409,2020,A Location in patent:Paragraph 0046; 0049

1-BROMO-4-(2,2-DIETHOXY-ETHYLSULFANYL)-BENZENE

96804-05-6
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5-BROMOBENZO[B]THIOPHENE

4923-87-9
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$6.00/1g

References
1,3-Benzodioxole-5-propanoic acid, 7-methoxy-α-thioxo-

874497-39-9
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5-BROMOBENZO[B]THIOPHENE

4923-87-9
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References
5-BROMO-1-BENZOTHIOPHENE-2-CARBOXYLIC ACID

7312-10-9
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$33.00/250mg

5-BROMOBENZO[B]THIOPHENE

4923-87-9
252 suppliers
$6.00/1g

References
Benzo[b]thiophene-3-ol, 5-bromo-2,3-dihydro-

911472-08-7
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5-BROMOBENZO[B]THIOPHENE

4923-87-9
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References

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