5-BroMobenzothiophene-2-carboxylic Acid Methyl Ester synthesis
- Product Name:5-BroMobenzothiophene-2-carboxylic Acid Methyl Ester
- CAS Number:7312-11-0
- Molecular formula:C10H7BrO2S
- Molecular Weight:271.13
149947-15-9
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7312-11-0
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Yield:7312-11-0 97.7%
Reaction Conditions:
with pyridine in (methylsulfinyl)methane at 60 - 120;Inert atmosphere;
Steps:
5 Example 5:
To the 1000ML reactor, add 3-bromo-2-fluorobenzaldehyde (30.0g, 0.15mol), dissolve in 300ml dimethyl sulfoxide, add pyridine (33.3g, 0.45mol), and then dropwise add thioglycolic acid Methyl ester (15.9g, 0.15mol) was heated to 60°C-120°C under nitrogen protection, heated for 1-5 hours, cooled to room temperature after the reaction was completed, extracted with ethyl acetate and water, and the organic phase was dried with suction filtration, The obtained filtrate was concentrated under reduced pressure to obtain the intermediate S9,5-bromobenzothiophene-2-carboxylic acid methyl ester, 39.7 g, HPLC=96.2, yield 97.7%.
References:
CN114907335,2022,A Location in patent:Paragraph 0070-0072
2365-48-2
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93777-26-5
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7312-11-0
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![5-BROMOBENZO[B]THIOPHENE](http://hg.y866.cn/chemistry/CAS/GIF/4923-87-9.gif)
4923-87-9
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124-38-9
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74-88-4
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7312-11-0
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$25.00/100mg