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〖合成方法〗Etilevodopa has been obtained by several different methods: (i) esterification of 3-hydroxy-L-tyrosine (I) (L-DOPA) with ethanol catalyzed by dry HCl gas; (ii) esterification of 3-hydroxy-L-tyrosine (I) (L-DOPA) by means of SOCl2 in hot ethanol; (iii) enzymatic hydroxylation of L-tyrosine ethyl ester (II) by means of mushroom tyrosinase in a phosphate buffer. 〖作者〗Sorbera, L.A.; Leeson, P.; Casta馿r, J.; Mart韩, L. 〖参考〗Sorbera, L.A.; Leeson, P.; Casta馿r, J.; Mart韩, L.; Etilevodopa. Drugs Fut 2001, 26, 3, 219 〖出处〗Drugs Fut2001,26,(3):219 〖备注〗Synthesis of Etilevodopa (EN:134939): Etilevodopa has been obtained by several different methods: (i) esterification of 3-hydroxy-L-tyrosine (I) (L-DOPA) with ethanol catalyzed by dry HCl gas (1); (ii) esterification of 3-hydroxy-L-tyrosine (I) (L-DOPA) by means of SOCl2 in hot ethanol (2); (iii) enzymatic hydroxylation of L-tyrosine ethyl ester (II) by means of mushroom tyrosinase in a phosphate buffer (3) (Scheme 13493901a). Manufacturer Teva Pharmaceutical Industries Ltd. (IL); licensed to H. Lundbeck A/S (DK) for Europe. References 1. Lidor, R., Bahar, E., Frenkel, A. (Teva Pharmaceutical Industries Ltd.; Teva Pharmaceuticals USA, Inc.). Process for manufacture of L-DOPA ethyl ester. WO 0027801. 2. Milman, I., Veinberg, A., Atlas, D., Melamed, E. (Yissum Research Development Co.; Teva Pharmaceutical Industries Ltd.). Process for preparing ethyl ester of L-DOPA. EP 0610595, US 5354885. 3. Ahmed, G., Vulfson, E.N. Facile synthesis of L-dopa esters by the combined use of tyrosinase and a-chymotrypsin. Biotechnol Lett 1994, 16: 367-72.
