甘氨熊胆酸的合成路线有哪些？

基本信息：中文名称 甘氨熊胆酸中文别名 (S)-(+)-4-(2,3-环氧基丙氧基)咔唑;英文名称 (S)-(+)-4-(2,3-Epoxypropoxy)carbazole英文别名 4-(2-hydroxy-5,7-dimethyl-4-oxo-6,8-nonadienyl)-2,6-piperidinedione;streptimidone;Protomycin;Streptoimidone;(S)-2-(carbazol-4-yl-oxymethyl)oxirane;4-[(2S)-oxiranylmethoxy]-9H-carbazole;4-(L-erythro-2-hydroxy-5,7-dimethyl-4-oxo-nona-6t,8-dienyl)-piperidine-2,6-dione;(S)-4-(2,3-epoxypropoxy)carbazole;4-[(2R,5S,6E)-2-Hydroxy-5,7-dimethyl-4-oxo-6,8-nonadienyl]-2,6-piperidinedione;S-(+)-4-(oxiranylmethoxy)-9H-carbazole;Streptimidon;4-[(2S)-oxiran-2-ylmethoxy]-9H-carbazole;(S)-3-(9H-carbazol-4-yloxy)-1,2-epoxypropane;4-(L-erythro-2-Hydroxy-5,7-dimethyl-4-oxo-nona-6t,8-dienyl)-piperidin-2,6-dion;4-[(2'R,5'S,6'E)-2'-hydroxy-5',7'-dimethyl-4'-oxonona-6',8'-dienyl]piperidine-2,6-dione;CAS号 95093-95-1合成路线：1.通过4-羟基咔唑和(S)-(+)- 间硝基苯磺酸缩水甘油酯合成甘氨熊胆酸，收率约93%；2.通过(R)-(−)-环氧氯丙烷和4-羟基咔唑合成甘氨熊胆酸，收率约52%；更多路线和参考文献可参考http://baike.molbase.cn/cidian/1556411