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Irreversible inhibitor of cysteine proteinases like papain, calpain, cathepsin B, L and H. Acts by forming a thioether bond with the thiol of the active cysteine. Does not inhibit serine proteinases. Inhibits degradation of autophagic cargo in autophagolysosomes.
E-64是半胱氨酸蛋白酶(如木瓜酶,蛋白酶,组织蛋白酶B、L和H)的不可逆抑制剂。通过与活性半胱氨酸的巯基形成硫醚键来发挥作用。不抑制丝氨酸蛋白酶活性。可以抑制自噬
Formula分子式: C15H27N5O5 . 0.5 H20
MW分子量: 357.4
Appearance性状: White to off-white solid. 白色-米白色固体
Solubility溶解性: Soluble in DMSO or water (4mg/ml).可溶解于DMSO或水中
Long Term Storage长期保存: -20°C
Handling处理: Protect from light. 避光操作