7-氯-1-乙基-6-氟-1,4-二氢-4-氧代喹啉-3-羧酸乙酯的合成路线有哪些？

基本信息：
中文名称 7-氯-1-乙基-6-氟-1,4-二氢-4-氧代喹啉-3-羧酸乙酯
中文别名 7-氯-1-乙基-6-氟-1,4-二氢-4-氧代-喹啉-5-羧酸乙酯;
英文名称 ethyl 7-chloro-1-ethyl-6-fluoro-4-oxoquinoline-5-carboxylate
英文别名 7-chloro-1-ethyl-6-fluoro-4-oxo-5-quinolinecarboxylic acid ethyl ester;ethyl-1-ethyl-6-fluoro-7-chloro-4-oxo-1,4-dihydro-quinoline-3-carboxylate;ETHYL 7-CHLORO-1-ETHYL-6-FLUORO-1,4-DIHYDRO-4-OXO-QUINOLINE-5-CARBOXYLATE;3-Quinolinecarboxylic acid,7-chloro-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-,ethyl ester;7-chloro-3-ethoxy-carbonyl-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline;ethyl 7-chloranyl-1-ethyl-6-fluoranyl-4-oxidanylidene-quinoline-5-carboxylate;1-ethyl-6-fluoro-7-chloro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester;ethyl 7-chloro-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate;7-chloro-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid,ethyl ester;
CAS号 70458-94-5

合成路线：
1.通过7-氯-6-氟-4-4羟基-3-喹啉甲酸乙酯和碘乙烷合成7-氯-1-乙基-6-氟-1,4-二氢-4-氧代喹啉-3-羧酸乙酯，收率约91%；

2.通过溴乙烷和7-氯-6-氟-4-4羟基-3-喹啉甲酸乙酯合成7-氯-1-乙基-6-氟-1,4-二氢-4-氧代喹啉-3-羧酸乙酯，收率约91%；

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