证明计沙要(3-4cos2A+con4A)/(3+4cos2A+cos4A)=tan^4A

TAN-来自67
【化学名】(-)-(4aS*,12aR*)-4a-(3-Hydroxyphenyl)-2-methyl-1,2,3,4,4a,5,12,12a-octahydropyrido[3,4-b]acridine
【CAS登记号】【结构式】
360问答【分子式】C23-H24-N2-O
【分子量】344.4556
【原研厂家】Toray (Originator)
【作用类别】ANALGESIC AND ANESTHETIC DRUGS, Analgesic Drugs盾要祖他旧兴便认正过, ****** Analgesics, delta认济化出继设包木述-****** Agonists
【研发状态】Preclinical
【合成情况】
〖来源〗Chem Pharm Bull
〖合成路线〗
〖标题〗Rational drug des黑ign and synthesis of a highly selective nonpepti械九现请初对造程写居de delt-opioi刑境黄溶审改举布d agonist, (4aS*,12aR*)-4a-(3-hydroxyphenyl)-2-met环使击扬这连hyl-1,2,3,4,4a,5,12,12a-octrahydropyrido[3,4-b]acridine (TAN-67工妈支)
〖合成方法〗The cyc汽lization of perhydroisoquinoline (I) with o-amino-benzaldehyde 金严威距始张粒众谁风(II) in the presence of methanesulfonic acid in refluxing EtOH gave the pyridoacridine (III). Sub种溶关sequent cleavage of the methyl ether function usin女道坐双水显g n-PrSH and tert-BuOK in boiling DMF provided the target phenol.
〖作者〗Nagase, H.; Kawai, K.; Hayakawa, J.; Wakita群, H.; Mizusuna, A.; Matsuura, H.; Tajima, C.; Takezawa, Y.; Endoh, T.
〖参考〗Nagase, H.; Kawai, K.; Hayakawa, J.; Wakita, H.; Mizusuna, A.; Matsuura, H.子; Tajima, C.; Takezawa, Y.; Endoh, T.; Rational drug design and synthesis of a highly selective nonpeptide delt-****** agonist命班理, (4aS*,12aR*)-4a-(3-hydroxyphenyl)-2-methyl-1,2点乙,3,4,4es/10_5_hkavynmfxxnmvbvo.html">eIǚ Ꚑݐul> li>a href="http://hg.y866.cn/compound/databases/10_1_vqrupomukvaqu
〖出处〗Chem Pharm Bull1998,46,(11):1班695
〖备注〗The cyclization of perh去重ydroisoquinoline (I) with o-amino-benzaldehyde (II) in the presence of methanesulfonic acid in refluxing EtOH gave the pyridoacridine (III). Subsequent cleavage of the methyl ether function using n-PrSH and tert-BuOK in boiling DMF provided the target phenol (1).
〖来源〗Symp Med Chem
〖合成路线〗
〖标题〗Rational drug design and synthesis of ****** delta-receptor selective nonpeptidic agonists - Optical resolution of (? TAN-67 and the pharmacological effect of each enantiomer
〖合成方法〗The cyclization of perhydroisoquinoline (I) with o-amino-benzaldehyde (II) in the presence of methanesulfonic acid in refluxing EtOH gave the pyridoacridine (III). Subsequent cleavage of the methyl ether function using n-PrSH and tert-BuOK in boiling DMF provided the target phenol.
〖作者〗Fujii, H.; et al.
〖参考〗Fujii, H.; et al.; Rational drug design and synthesis of ****** delta-receptor selective nonpeptidic agonists - Optical resolution of (? TAN-67 and the pharmacological effect of each enantiomer. Symp Med Chem 1999, Abst 1P-21
〖出处〗Symp Med Chem1999,,():Abst 1P-21