编号 毒性类型 测试方法 测试对象 使用剂量 毒性作用 1 急性 口服 啮齿动物- rat 1947 mg/kg 1.Details of toxic effects not reported other than lethal dose value 2 急性 Inhalation 啮齿动物- rat 14 gm/m3/8H 1.Details of toxic effects not reported other than lethal dose value 3 急性 Intraperitoneal 啮齿动物- rat 1100 mg/kg 1.Details of toxic effects not reported other than lethal dose value 4 急性 口服 啮齿动物- mouse 860 mg/kg 1.Details of toxic effects not reported other than lethal dose value 5 急性 Inhalation 啮齿动物- mouse 1000 ppm/2H 1.Details of toxic effects not reported other than lethal dose value 6 急性 Unreported 啮齿动物- mouse 960 mg/kg 1.胃肠道毒性Gastrointestinal - ulceration or bleeding from stomach 2.胃肠道毒性Gastrointestinal - ulceration or bleeding from small intestine 7 急性 口服 Mammal - dog 5 mg/kg 1.行为毒性Behavi口服- sleep 2.肝毒性Liver - other changes 8 急性 Administration onto the skin 啮齿动物- rabbit 8750 uL/kg 1.Details of toxic effects not reported other than lethal dose value 9 急性 口服 啮齿动物- guinea pig 2 mg/kg 1.Details of toxic effects not reported other than lethal dose value 10 MutipleDose 口服 啮齿动物- rat 435 mg/kg/30D-I 1.血液毒性Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) 2.生化毒性Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases 3.生化毒性Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other Enzymes 11 MutipleDose 口服 啮齿动物- rat 28 mg/kg/14D-I 1.肾、输尿管和膀胱毒性Kidney, Ureter, Bladder - other changes 2.慢性病相关毒性Related to Chronic Data - death 12 MutipleDose 口服 啮齿动物- rat 109 mg/kg/26W-I 1.胃肠道毒性Gastrointestinal - changes in structure or function of endocrine pancreas 2.生化毒性Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other hydrolases 13 MutipleDose 口服 啮齿动物- rat 16250 mg/kg/13W-I 1.肝毒性Liver - changes in liver weight 2.内分泌毒性Endocrine - changes in spleen weight 3.生化毒性Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases 14 MutipleDose Inhalation 啮齿动物- rat 9 mg/m3/24H/94D-C 1.大脑毒性Brain and Coverings - recordings from specific areas of CNS 2.肺部、胸部或者呼吸毒性Lungs, Thorax, or Respiration - other changes 3.生化毒性Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase 15 MutipleDose Inhalation 啮齿动物- rat 10 mg/m3/24H/60D-I 1.肝毒性Liver - other changes 2.生化毒性Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases 3.生化毒性Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases 16 MutipleDose Inhalation 啮齿动物- rat 1000 ppm/7H/20W-I 1.肝毒性Liver - fatty liver degeneration 2.血液毒性Blood - changes in spleen 3.慢性病相关毒性Related to Chronic Data - death 17 MutipleDose Intraperitoneal 啮齿动物- rat 2500 mg/kg/5D-I 1.肝毒性Liver - other changes 2.生化毒性Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other transferases 18 MutipleDose Intraperitoneal 啮齿动物- rat 1400 mg/kg/4W-I 1.肝毒性Liver - other changes 2.生化毒性Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other transferases 19 MutipleDose 口服 啮齿动物- mouse 28 mg/kg/14D-I 1.肾、输尿管和膀胱毒性Kidney, Ureter, Bladder - other changes 2.慢性病相关毒性Related to Chronic Data - death 20 MutipleDose 口服 啮齿动物- mouse 32500 mg/kg/13W-I 1.慢性病相关毒性Related to Chronic Data - death 21 MutipleDose Inhalation 啮齿动物- mouse 400 ppm/7H/7W-I 1.肝毒性Liver - fatty liver degeneration 2.慢性病相关毒性Related to Chronic Data - death 22 MutipleDose Inhalation Mammal - dog 1000 ppm/7H/26W-I 1.肝毒性Liver - fatty liver degeneration 2.肾、输尿管和膀胱毒性Kidney, Ureter, Bladder - changes in tubules (including 急性renal failure, 急性tubular necrosis) 3.内分泌毒性Endocrine - other changes 23 MutipleDose Inhalation 啮齿动物- guinea pig 1500 ppm/7H/8W-I 1.肝毒性Liver - fatty liver degeneration 2.内分泌毒性Endocrine - other changes 3.慢性病相关毒性Related to Chronic Data - death 24 SkinEyeIrrition Administration into the eye 啮齿动物- rabbit 500 mg 1.Mild 25 Mutation Bacteria - Salmonella typhimurium 100 ug/plate 26 Mutation 啮齿动物- mouse Lymphocyte 11600 ug/L 27 Mutation 啮齿动物- hamster Ovary 660 mg/L 28 Mutation 啮齿动物- hamster Ovary 113 mg/L 29 Mutation 啮齿动物- hamster Lung 3300 umol/L 30 Tumorigenic 口服 啮齿动物- mouse 130 mg/kg/2Y-I 1.致癌性Tumorigenic - Carcinogenic by RTECS criteria 2.皮肤和附件毒性Skin and Appendages - tumors 31 Reproductive 口服 啮齿动物- rat 1250 mg/kg,female 6-15 day(s) after conception 1.生殖毒性Reproductive - Maternal Effects - other effects 32 Reproductive 口服 啮齿动物- rabbit 1950 mg/kg,female 7-19 day(s) after conception 1.生殖毒性Reproductive - Maternal Effects - other effects
