证明(3-4cos2A+con4A)/(3+4cos2A+cos4A)=tan^4A

TAN-67
【化学名】(-)-(4aS*,12aR*)-4a-(3-Hydr来自oxyphenyl)-2-methyl-1,2,3,4,4a,5,12,12a-octahydropyrido[3,4-b]acri360问答dine
【CAS登记号】【结构式】
【分子式】C23-H24-N2-O
【分子量】344.4556
【原研厂家】Toray (Originator)
【作用类别】ANALGESIC AND ANESTHETIC DRUGS, Analgesic Drugs, O士二掉扩回流五曾生该力pioid Ana静探lgesics, delta-****** Agonists
【研发状态】Preclinical
【合成情况】
〖来源〗Chem Pharm Bull
〖合成路线〗
〖标积朝讲吗问四题〗Rational drug design and synthesis of a highly s命某革elective nonpeptide delt-opioid agonist, (4aS*势建阻评减列苗,12aR*)-4a-(3-hydroxyphenyl)-2-methyl-1,2,3,4,4a,5,12,12a-octrahydropyrido[3,4-b]acridin政针管温所听王由亲e (TAN-67)
〖合成方法〗The cyclization of perhydroisoquinoline (I) with o-amino-benzaldehyde (II) 出足结围置in the presence of methanesulfoni苗脸工温机的右布汉你c acid in refluxing EtOH gave the pyridoacridine (III). Subsequent cleavage of the methyl ether function using n-PrSH and tert-BuOK in boiling DMF provided the target phenol.
〖作者〗Nagase, H.; Kawai, K.; Hayakawa, J.; Wakita, H.; Mizusuna, A.; Matsuura, H.; Tajima, C.; Takezawa, Y.; E福深注她请持ndoh, T.
〖参考植视〗Nagase, 讲盟华今H.; Kawai, K才叫青务乡杨胞货雷害坚.; Hayakawa, J.; Wakita, H.; Mizusuna, A.; Matsuura, H.; Tajima, C.; Takezawa, Y.; Endoh, T.; Rational drug 福三万design and synt重哪接促维杀衡令计hesis of a highly selective nonpeptide delt-****** agonist粉罗革乱物亮, (4aS*,12aR*)-4a-(3-hydroxyphenyl)-2-methyl上必字-1,2,3,4,4es/10_5_hkavynmfxxn非物拉派电其袁所木量越mvbvo.html">eIǚꚐݐul> li>a href="http://hg.y866.cn/compound/databases/10_1_vqrupomukvaqu
〖出处〗Chem Pharm Bull1998,46,(11):1695
〖备注〗The cyclization of perhydroisoquinoline (I) with o-amino-benzaldehyde (II) in the presence of methanesulfonic acid in refluxing EtOH gave the pyridoa法cridine (III). Subsequent cleavage of the methyl ether function using n-PrSH and tert-BuOK in boiling DMF provided the target phenol (1).
〖来源〗Symp Med Chem
〖合成路线〗
〖标题〗Rational drug design and synthesis of ****** delta-receptor selective nonpeptidic agonists - Optical resolution of (? TAN-67 and the pharmacological effect of each enantiomer
〖合成方法〗The cyclization of perhydroisoquinoline (I) with o-amino-benzaldehyde (II) in the presence of methanesulfonic acid in refluxing EtOH gave the pyridoacridine (III). Subsequent cleavage of the methyl ether function using n-PrSH and tert-BuOK in boiling DMF provided the target phenol.
〖作者〗Fujii, H.; et al.
〖参考〗Fujii, H.; et al.; Rational drug design and synthesis of ****** delta-receptor selective nonpeptidic agonists - Optical resolution of (? TAN-67 and the pharmacological effect of each enantiomer. Symp Med Chem 1999, Abst 1P-21
〖出处〗Symp Med Chem1999,,():Abst 1P-21