如何无菌无热原

无菌sterility是指在给则践任一指定的物体、介质或环境中无任何活的微生物。
Refers to any given object, medium or environment, without any living organisms.
除菌：使用物理、化学灭菌法Using physical, chemical sterilization and Asepticmeth术局议功往同扬触od如：0.22μm的微孔滤膜除菌、使用消毒剂、防腐剂。无菌操作法。0.22μm microporous membr究安ane, the use of disinfectants and pr积货把十概eservatives.
热原pyrogen
停铁是指够致热的微生物的尸体及其代谢产物，即微生物的一种内毒素，是由磷脂、脂多糖和蛋白质伯武帝沿所组成的复合物，脂多糖是主要成分，具有特别强的热原活性。
Refers to the bodies of Microorganisms and its metabolites that can cause fever, that is a kind of micro普新绿素食衡-organisms endotoxin, which is a kind of compl两让合活延未尔化员输面ex composed of 临统动格法缺接映究华委phospholipids LPS and protein, LPS is a major component, with particularly strong p况喜号异尽整优守丝光饭yrogen activity.
热原具耐热性、滤印价初国目认因工在的适过性、水溶性、不挥发性、被吸附性。
去除热源：高温法、酸碱法、吸附法、离子交换法、凝胶过滤法、反渗透法。活性碳常温吸附
High-temperature method, pH, adsorption, ion exc多觉山阻hange, gel filtration, reverse osmosis. Activated ca宣提方延未模且rbon adsorption at room temperature
除氧，尽量减少药物与空气的接触，在货兰章全深缩品配液和灌封中通入惰性气体，常用高纯度的氮气和二氧化碳。(2)加抗氧剂。(3)调节溶液pH在最稳定pH范围。(4)加武逐厂门使似杨便每个金属离子络合剂。
Oxyg福免争由望继en, drugs to mi爱位报希编nimize contact with air, in communication with fluid and potting ininert gas, commonly used in high-p他收际米urity nitrogen and carbon dioxide. (2) plusantioxidants. (3) adjusting the solution pH in the most stable pH range. (4) with metalion complexing agent.