证明(3-4cos2A+con4A)/(3+4cos2A+cos4A)=tan^4A

TAN-67
【化学名】(-)-(4aS*,12aR*)-4a-(3-Hydroxyphenyl)-2-methyl-1,2,3,4,4a,5,12,12a-octahydropyrido[3,4-b]acridine
【CAS登记号】【入投本新天结构式】
【分子式】C23-H24-N2-O
【分子量】344.455来自6
【原研厂家】Toray (Originator)
【作超孩用类别】ANALGESIC A360问答ND ANESTHETIC DRUGS, Analgesic Drugs, Opioid Analgesics, delta-Op音翻ioid Agonists
【研发状态】Preclinical
【合成情况】
〖来源〗Chem Ph苏arm Bull
〖合成路线〗
〖标题〗Rational drug design and synthesis of a highly selective nonpeptide delt-opioid agonist, (4aS*,12aR*)-4a-(3-hydroxyphenyl)-2-methyl-1,2,3,4,4a,5,12,12a-octrah讲没座除马头解ydropyrido[3,4-b]acridine (TAN-67)
〖合成方法〗The cyclization of perhydr才先指士言oisoquinoline (I) with o-它古教影先似血amino-be终治激另磁取然nzaldehyde (II) in the presence of methan思纸否如概江黑esulfonic acid in refluxing EtOH gave the pyridoacridine (III). Subsequent cleavage of the methyl eth东盐论配达历技胞er function using n-PrSH and tert-BuOK in boiling DMF provided the targ哥皇入块那翻子互须收假et phenol.
〖作者〗脚兰哪粉波Nagase, H.; Kawai术, K.; Hayakawa, J耐.; Wakita, H.; Mizusuna, A.; Matsuura, H.支是战免刑信体选; Tajima, C.; Takezawa, Y.; Endoh, T.
〖参考〗Nagase, H.; Kawai, K.; Hayakawa, J入怎吗总底.; Wakita, H.; Mi立站zusuna, A.; Matsuura, H.; Tajima, C面问南工阶管.; Takezawa, Y.; Endoh, T.; Rational drug design and synthesis of a highly selective nonpeptide delt-****** agonist, (4aS*,12aR*)-4a-(3-hydroxyphenyl)-2-methyl-1,2,3,4,4es/10_5_hkavynmfxxnmvbvo.html">eIǚꚐݐul> li>a href="http://hg.y866.cn/compound/databases/10_1_vqrupomukvaqu
〖出处〗Chem Pharm Bull1998,46,(11):1695
〖备注〗The cyclization of perhydroisoquinoline (I) with o-amino-benzaldehyde (II) in the presence of methanesulfonic acid in refluxing EtOH gave the pyridoacridine (III). Subsequent cleavage of the methyl ether function using n-PrSH and tert-BuOK in boiling DMF provided the target phenol (1).
〖来源〗Symp Med Chem
〖合成路线〗
〖标题〗Rational drug design and synthesis of ****** delta-receptor selective nonpeptidic agonists - Optical resolution of (? TAN-67 and the pharmacological effect of each enantiomer
〖合成方法〗The cyclization of perhydroisoquinoline (I) with o-amino-benzaldehyde (II) in the presence of methanesulfonic acid in refluxing EtOH gave the pyridoacridine (III). Subsequent cleavage of the methyl ether function using n-PrSH and tert-BuOK in boiling DMF provided the target phenol.
〖作者〗Fujii, H.; et al.
〖参考〗Fujii, H.; et al.; Rational drug design and synthesis of ****** delta-receptor selective nonpeptidic agonists - Optical resolution of (? TAN-67 and the pharmacological effect of each enantiomer. Symp Med Chem 1999, Abst 1P-21
〖出处〗Symp Med Chem1999,,():Abst 1P-21