14182-01-5 ((E)-2-甲基-1,3-二苯基-2-丙烯-1-酮,2-Propen-1-one, 2-methyl-1,3-diphenyl-, (2E)-)

反应条件：

1.1R:KOH, S:EtOH, rt; 3 d, rt
1.2R:H2O, rt

参考文献：

Intramolecular oxidative C-N bond formation under metal-free conditions: One-pot global functionalization of pyrazole ring

By Tiwari, Mohit K. et al, Tetrahedron, 2022, 126, 133059

合成路线：1 步

反应条件：

1.1R:Piperidine, R:AcOH, S:EtOH, 18 h, reflux

参考文献：

A facile metal-free one-flask synthesis of multi-substituted furans via a BF3·Et2O mediated formal [4 + 1] reaction of 3-chloro-3-phenyldiazirines and α,β-alkenyl ketones

By Zhang, Zixin et al, RSC Advances, 2022, 12(24), 15190-15195

合成路线：1 步

_65%

反应条件：

1.1R:NaOH, S:EtOH, rt → 70°C; 12 h, 70°C
1.2R:HCl, S:H2O, pH 2

参考文献：

Design, Synthesis, and Biological Evaluation of Organic Nitrite (NO2-) Donors as Potential Anticerebral Ischemia Agents

By Wu, Jianbing et al, Journal of Medicinal Chemistry, 2021, 64(15), 10919-10933

合成路线：1 步

3699-66-9

_55%

反应条件：

1.1R:NaH, S:THF, 0°C; 30 min, 0°C
1.2overnight, rt
1.3R:NH4Cl, S:H2O, rt
1.4R:MeNHOMe-HCl, R:i-PrMgCl, S:THF, 30 min, 0°C; 1 h, rt
1.5R:NH4Cl, S:H2O, rt
1.6S:THF, 0°C; 1 h, rt
1.7R:NH4Cl, S:H2O, rt

参考文献：

Iridium-catalyzed enantioconvergent hydrogenation of trisubstituted olefins

By Peters, Bram B. C. et al, Nature Communications, 2022, 13(1), 361

合成路线：1 步

反应条件：

1.1R:Cs2CO3, C:2000210-49-9, S:HOCMe2Et, 24 h, 135°C

参考文献：

Manganese(I) catalyzed cross-coupling of secondary allylic alcohols and primary alcohols

By Pandia, Biplab Keshari et al, Tetrahedron, 2021, 101, 132472

合成路线：1 步

反应条件：

1.1S:EtOH, 30 min, rt
1.2R:NaOH, S:H2O, rt

参考文献：

Substituent-Controlled Divergent Cascade Cycloaddition Reactions of Chalcones and Arylalkynols: Access to Spiroketals and Oxa-Bridged Fused Heterocycles

By Zeng, Tianlong et al, Advanced Synthesis & Catalysis, 2021, 363(16), 4024-4032

合成路线：3 步

反应条件：

1.1R:NaH, S:THF, 0°C; 30 min, 0°C
1.2overnight, rt
1.3R:NH4Cl, rt
2.1R:i-PrMgCl, S:THF, 30 min, 0°C; 1 h, rt
2.2R:NH4Cl, rt
3.1S:THF, 0°C; 1 h, rt
3.2R:NH4Cl, rt

参考文献：

Highly enantioselective iridium-catalyzed hydrogenation of conjugated trisubstituted enones

By Peters, Bram B. C. et al, Organic Letters, 2021, 23(1), 242-246

合成路线：1 步

_22%

反应条件：

1.1R:NaOH, R:O2, S:MeOH, S:H2O, rt; 2 d, reflux
1.2R:HCl, S:H2O

参考文献：

Chemoselective Reduction of α,β-Unsaturated Carbonyl and Carboxylic Compounds by Hydrogen Iodide

By Matsumoto, Shoji et al, Bulletin of the Chemical Society of Japan, 2021, 94(2), 590-599

合成路线：1 步

103-49-1

_57%

反应条件：

1.1R:(NH4)2S2O8, S:HOCMe2Et, 20 h, 120°C

参考文献：

New photochromic α-methylchalcones are highly photostable, even under singlet oxygen conditions: breaking the α-methyl Michael-system reactivity by reversible peroxybiradical formation

By Griesbeck, Axel G. et al, Molecules, 2021, 26(3), 642

合成路线：1 步

反应条件：

1.1R:Piperidine, R:AcOH, S:EtOH, 13 h, 85°C
1.2R:NH4Cl, S:H2O

参考文献：

H-*BEA Zeolite-Catalyzed Nucleophilic Substitution in Allyl Alcohols Using Sulfonamides, Amides, and Anilines

By Ohtsuki, Akimichi et al, European Journal of Organic Chemistry, 2020, 2020(28), 4309-4318

合成路线：1 步

反应条件：

1.1C:5588-84-1, C:EtN(Pr-i)2, S:PhMe, 16 h, 100°C

参考文献：

Oxovanadium(V)-catalyzed deoxygenative homocoupling reaction of alcohols

By Sakuramoto, Takashi et al, New Journal of Chemistry, 2019, 43(45), 17571-17576

合成路线：1 步

_63%

反应条件：

1.1R:KOH, S:H2O, S:EtOH, 3 d, rt

参考文献：

Stereodivergent Access to Enantioenriched Epoxy Alcohols with Three Stereogenic Centers via Ruthenium-Catalyzed Transfer Hydrogenation

By Zhao, Zhifei et al, Organic Letters, 2019, 21(14), 5491-5494

合成路线：1 步

反应条件：

1.1R:NaOH, S:H2O, S:EtOH, 0°C; 0°C → rt; 2 h, rt

参考文献：

Proton-Coupled Electron Transfer: Transition-Metal-Free Selective Reduction of Chalcones and Alkynes Using Xanthate/Formic Acid

By Prasanna, Ramanathan et al, Organic Letters, 2019, 21(8), 2650-2653

合成路线：1 步

反应条件：

1.1R:Me3SiSO3CF3, R:EtN(Pr-i)2, S:CH2Cl2, rt; 16 h, rt

参考文献：

Chalcone and cinnamate synthesis via one-pot enol silane formation-Mukaiyama aldol reactions of ketones and acetate esters

By Downey, C. Wade et al, Tetrahedron Letters, 2018, 59(32), 3080-3083

合成路线：1 步

反应条件：

1.1C:Pd(PPh3)4, S:Dioxane, 3 h, 25°C

参考文献：

α,β-Diaryl unsaturated ketones via palladium-catalyzed ring-opening of cyclopropenones with organoboronic acids

By Shan, Lidong et al, Organic Chemistry Frontiers, 2018, 5(10), 1651-1654

合成路线：1 步

98-86-2

_66%

反应条件：

1.1R:AcOH, C:Piperidine, S:EtOH, 18 h, 60°C

参考文献：

Synthesis and biological evaluation of α-methyl-chalcone for anti-cervical cancer activity

By Ren, Bing-zhao et al, Medicinal Chemistry Research, 2017, 26(9), 1871-1883

合成路线：1 步

_36%

反应条件：

1.1C:CBr4, 27 h, 60°C
1.2R:NaHSO3, S:H2O, 60°C

参考文献：

CBr4 as a Halogen Bond Donor Catalyst for the Selective Activation of Benzaldehydes to Synthesize α,β-Unsaturated Ketones

By Kazi, Imran et al, Organic Letters, 2017, 19(5), 1244-1247

合成路线：1 步

_42%

反应条件：

1.1R:TiCl4, S:CH2Cl2, 5 min, 0°C
1.2R:Et3N, S:CH2Cl2, 0°C; 1 h, 0°C
1.3R:Et3N, S:CH2Cl2, 5 min, 0°C
1.4R:MeSO2Cl, 5 h, 0°C
1.5R:DBU, 0°C → rt; 16 h, rt

参考文献：

Zinc-Catalyzed Enantioselective Hydrosilylation of Ketones and Imines under Solvent-Free Conditions

By Szewczyk, Marcin et al, ChemCatChem, 2016, 8(23), 3575-3579

合成路线：1 步

673-32-5

_70%

反应条件：

1.1C:Py2I+ •-BF4, C:HBF4, S:CH2Cl2, 10 min, 0°C
1.21 h, rt
1.3R:NaHCO3, R:Na2S2O3, S:H2O

参考文献：

Barluenga's reagent with HBF4 as an efficient catalyst for alkyne-carbonyl metathesis of unactivated alkynes

By Murai, Kosuke et al, Organic & Biomolecular Chemistry, 2016, 14(44), 10352-10356

合成路线：1 步

673-32-5

_90%

反应条件：

1.1R:H2O, 20 h, 100°C

参考文献：

Synthesis of α,β-unsaturated ketones from alkynes and aldehydes over Hβ zeolite under solvent-free conditions

By Mameda, Naresh et al, RSC Advances, 2016, 6(63), 58137-58141

合成路线：1 步

反应条件：

1.1R:Ti(OPr-i)4, R:BuLi, S:THF, -78°C; -78°C → rt; rt
1.2R:H2O

参考文献：

Regioselective Synthesis of Enones via a Titanium-Promoted Coupling of Unsymmetrical Alkynes with Weinreb Amides

By Silwal, Sajan and Rahaim, Ronald J., Journal of Organic Chemistry, 2014, 79(17), 8469-8476

合成路线：1 步

反应条件：

1.1R:SnCl2, C:BuOH, S:MeNO2, 3 h, 80°C

参考文献：

Tin(II) Chloride Mediated Coupling Reactions between Alkynes and Aldehydes

By Masuyama, Yoshiro et al, European Journal of Organic Chemistry, 2013, 2013(35), 8033-8038

合成路线：1 步

103-83-3

_11%

反应条件：

1.1R:(NH4)2S2O8, S:HOCMe2Et, 24 h, 120°C

参考文献：

Practical metal-free synthesis of chalcone derivatives via a tandem cross-dehydrogenative-coupling/elimination reaction

By Wei, Yu et al, Green Chemistry, 2013, 15(11), 3165-3169

合成路线：1 步

_29%

反应条件：

1.1R:KOH, S:H2O, S:EtOH, 5 h, 100°C

参考文献：

InCl3/Me3SiCl-Catalyzed Direct Michael Addition of Enol Acetates to α,β-Unsaturated Ketones

By Onishi, Yoshiharu et al, Organic Letters, 2012, 14(22), 5788-5791

合成路线：1 步

_75%

反应条件：

1.1S:EtOH, heated
1.2R:NaOH, S:H2O, S:EtOH
1.3rt; 1 h, rt; rt → 60°C; reflux

参考文献：

Synthesis of Tri- and Tetrasubstituted Pyrazoles via Ru(II) Catalysis: Intramolecular Aerobic Oxidative C-N Coupling

By Hu, Jiantao et al, Organic Letters, 2012, 14(19), 5030-5033

合成路线：1 步

_50%

反应条件：

1.1R:H2SO4, S:H2O, S:AcOH

参考文献：

The diastereoselective alkylation of β-silyl enolates

By Waterson, David, No pp.; 1984, 1984, , From No pp.

合成路线：1 步

673-32-5

_98%

反应条件：

1.1C:128008-30-0, C:BuOH, rt → 100°C; 0.5-2 h, 100°C
1.2R:NaHCO3, S:H2O

参考文献：

Indium(III)-catalyzed coupling between alkynes and aldehydes to α,β-unsaturated ketones

By Miura, Katsukiyo et al, Chemistry Letters, 2010, 39(7), 766-767

合成路线：1 步

_42%

反应条件：

1.1R:F3CCO2H, C:12081-16-2, S:H2O, S:MeOH, 16 h, 80°C, pH 5

参考文献：

Rhodium catalyzed reaction of internal alkynes with organoborons under CO atmosphere: a product tunable reaction

By Artok, Levent et al, Tetrahedron, 2009, 65(45), 9125-9133

合成路线：1 步